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Novel synthetic sulfoglycolipid IG20 facilitates exocytosis in chromaffin cells through the regulation of sodium channels

Author
Crespo-Castrillo, Andrea; Punzón, Eva; Pascual, Ricardo de; Maroto, Marcos; Padín, Juan Fernando; García-Álvarez, Isabel; Nanclares, Carmen; Ruiz-Pascual, Lucía; Gandía Juan, Luisuntranslated; Fernández-Mayoralas, Alfonso; García, Antonio G.
Entity
UAM. Departamento de Farmacología
Publisher
John Wiley & Sons, Inc
Date
2015-12-01
Citation
10.1111/jnc.13357
Journal of Neurochemistry 135.5 (2015): 880-896
 
 
 
ISSN
0022-3042; 0022-3042
DOI
10.1111/jnc.13357
Funded by
This work was supported by grants from Ministerio de Economía y Competitividad, Spain (MINECO, SAF-2013-44108-P to AGG and LG; and FIS-PI11/01436 to AFM), Fundación Eugenio Rodríguez Pascual (to LG). We thank the continued support of Fundación Teófilo Hernando, Madrid, Spain
Project
Gobierno de España. SAF-2013-44108-P; Gobierno de España. FIS-PI11/01436
Editor's Version
http://dx.doi.org/10.1111/jnc.13357
Subjects
Compound IG20; Exocytosis; Sodium channel; Calcium channel; Sulfoglycolipid; Chromaffin cell; Medicina
URI
http://hdl.handle.net/10486/672389
Note
This is the peer reviewed version of the following article: Novel synthetic sulfoglycolipid IG20 facilitates exocytosis in chromaffin cells through the regulation of sodium channels: Journal of Neurochemistre, 135.5 (2015), which has been published in final form at http://dx.doi.org/10.1111/jnc.13357
Rights
© 2015 International Society for Neurochemistry

Abstract

In searching for druggable synthetic lipids as potential modulators of synaptic transmission and plasticity, we synthesized sulfoglycolipid IG20 that stimulates neuritic outgrowth. Here we have explored its effects on ion channels and exocytosis in bovine chromaffin cells (BCCs). IG20 augmented the rate of basal catecholamine release. Such effect did not depend on Ca2+ mobilization from intracellular stores; rather, IG20-elicited secretion entirely dependent on Ca2+ entry through Lsubtype voltage-activated Ca2+ channels. Those channels were recruited by cell depolarization mediated by IG20 likely through its ability to enhance the recruitment of Na+ channels at more hyperpolarizing potentials. Confocal imaging with fluorescent derivative IG20-NBD revealed its rapid incorporation and confinement into the plasmalemma, supporting the idea that IG20 effects are exerted through a plasmalemmal-delimited mechanism. Thus, synthetic IG20 seems to mimic several physiological effects of endogenous lipids such as regulation of ion channels, Ca2+ signaling, and exocytosis. Therefore, sulfoglycolipid IG20 may become a pharmacological tool to investigate the role of the lipid environment on neuronal excitability, ion channels, neurotransmitter release, synaptic efficacy, and neuronal plasticity. It may also inspire the synthesis of druggable sulfoglycolipids aimed at increasing synaptic plasticity and efficacy in neurodegenerative diseases and traumatic brain – spinal cord injury
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Google™ Scholar:Crespo-Castrillo, Andrea - Punzón, Eva - Pascual, Ricardo de - Maroto, Marcos - Padín, Juan Fernando - García-Álvarez, Isabel - Nanclares, Carmen - Ruiz-Pascual, Lucía - Gandía Juan, Luis - Fernández-Mayoralas, Alfonso - García, Antonio G.

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  • Producción científica en acceso abierto de la UAM [17202]

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