An intensive lifestyle intervention is an effective treatment of morbid obesity: The TRAMOMTANA study-a two-year randomized controlled clinical trial
Entity
UAM. Departamento de Medicina; Instituto de Investigación del Hospital de La Princesa (IP)Publisher
Hindawi Publishing CorporationDate
2015-01-01Citation
10.1155/2015/194696
International Journal of Endocrinology 2015 (2015): ID 194696
ISSN
1687-8337 (print); 1687-8345 (on line)DOI
10.1155/2015/194696Funded by
TRAMOMTANA was funded by a project grant from the Mutua Madrileña Medical Foundation and the Instituto de Salud Carlos III (ISCiii) (FIS: PI071250) and Spanish Clinical Research Network (CAIBER) which had no influence over the trial’s conductEditor's Version
http://dx.doi.org/10.1155/2015/194696Subjects
Morbid obesity; Treatment; Bariatric surgery; MedicinaRights
© 2015 Bartolomé Burguera et al.Abstract
Bariatric surgery is currently the most effective therapy to induce weight loss inmorbidly obese patients. Objective.This controlled,
clinical trial with a two-year intervention was aimed at comparing the efficacy of two nonsurgical approaches versus bariatric
surgery, on body weight changes and metabolic parameters in morbidly obese patients. Methods. Patients were randomized to an
Intensive Lifestyle Intervention (ILI) (𝑛 = 60) or Conventional Obesity Therapy (COT) (𝑛 = 46). The ILI group received behavioral
therapy and nutritional counseling. The COT group received standard medical treatment. They were compared with a third group,
Surgical Obesity Group (SOG) (𝑛 = 37). Results. Patients who received ILI had a greater percentage of weight loss than patients
receiving COT (−11.3% versus −1.6%; 𝑝 < 0.0044). Interestingly 31.4% of patients included in the ILI group were no longer morbidly
obese after just six months of intervention, increasing to 44.4% after 24 months of intervention.The percentage weight loss in SOG
was −29.6% after that same period of time. Conclusions. ILI was associated with significant weight loss when compared to COT, in
a group of patients with obesity. An ILI approach could be an alternative therapy to patients with obesity, who are not candidates
to undergo bariatric surgery. This trial is registered with EudraCT 2009-013737-24
Files in this item
Google Scholar:Burguera, Bartolomé
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Jesús Tur, Juan
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Escudero, Antonio Jorge
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Alos, María
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Pagán, Alberto
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Cortés, Baltasar
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González, Xavier Francesc
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Soriano, Joan B.
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