Serum lipid profile in subjects with traumatic spinal cord injury
Entity
UAM. Departamento de Medicina Preventiva y Salud Pública y MicrobiologíaPublisher
Public Library of ScienceDate
2015-02-23Citation
10.1371/journal. pone.0115522
PLoS ONE 10.2 (2015): e0115522.
ISSN
1932-6203DOI
10.1371/journal. pone.0115522Funded by
Dr. Laclaustra was supported in part by grants FIS CP08/00112 and PI10/00021 from the Spanish Instituto de Salud Carlos III. Dr. Castellote was supported in part by grants TPY 1115/07, PI13/ 00526, TPY 1444/08 and ESVI 1338/12-1 from the Instituto de Salud Carlos III. Dr. Hurtado was supported by Fellowship N°088-FINCyT-BDE-2014 from the Peruvian governmentEditor's Version
http://dx.doi.org/10.371/journal. pone.0115522Subjects
Spinal cord injury; Lipid profile; Degree of neurological involvement; MedicinaRights
© 2015 Laclaustra et alAbstract
Background and Aims
Few large studies have examined the relationship between spinal cord injury (SCI) and lipid
profile. We studied serum lipid concentrations in subjects with traumatic SCI in relation to
the degree of neurological involvement and time since injury, and compared them with values
from a reference sample for the Spanish population (DRECE study).
Materials and Methods
A retrospective cohort was built from 177 consecutive cases with traumatic SCI admitted to
the SCI unit of the Miguel Servet Hospital in Aragon (Spain). Outcome measures (cholesterol,
triglycerides, HDL-c and LDL-c levels) were analyzed according to the ASIA Impairment
Scale (AIS), neurological level of injury (involvement of all limbs vs. only lower limbs), and
time since injury. All analyses were adjusted for age and sex.
Results
Cases without preserved motor function (AIS A or B) had lower total and HDL cholesterol
than the others (-11.4 [-21.5, -1.4] mg/dL total cholesterol and -5.1 [-8.8, -1.4] mg/dL HDL-c),
and cases with all-limb involvement had lower total, HDL, and LDL cholesterol than those
with only lower-limb involvement (-14.0 [-24.6, -3.4]mg/dL total cholesterol, -4.1 [-8.0, -0.2]
mg/dL HDL-c, and -10.0 [-19.7, -0.3]mg/dL LDL-c) (all p<0.05). No association was found
between lipid concentrations and time since injury. Concentrations of lipid subfractions and triglycerides
in SCI subjects were lower than in sex- and age-stratified values fromthe
reference sample
Conclusion
A high degree of neurological involvement in SCI (anatomically higher lesions and AIS A or
B) is associated with lower total cholesterol and HDL-c
Files in this item
Google Scholar:Laclaustra, Martín
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Van Den Berg, Elizabeth Louise Maayken
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Hurtado-Roca, Yamilée
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Castellote, Juan Manuel
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