Establishment of a zebrafish infection model for the study of wild-type and recombinant European sheatfish virus
Entity
UAM. Departamento de Biología Molecular; Centro de Biología Molecular Severo Ochoa (CBM)Publisher
American Society for MicrobiologyDate
2015-01-01Citation
10.1128/JVI.01580-15.
Journal of Virology 89.20 (2015): 10702-10706
ISSN
0022-538XDOI
10.1128/JVI.01580-15.Funded by
This work was supported by grant AGL 2009-08711 from the Spanish Ministerio de Ciencia e Innovación and grant AGL2013-48998-C2-2-R from the Ministerio de Economía y Competitividad. G.A. was supported by the Amarouto Program for senior researchers from the Comunidad Autónoma de Madrid. A.L.B. and V.M. are holders of RyC-2010-06300 and RyC-2010-06516 Ramón y Cajal fellowships from the Spanish Ministerio de Ciencia e InnovaciónProject
Gobierno de España. AGL 2009-08711; Gobierno de España. AGL2013-48998-C2-2-REditor's Version
http://dx.doi.org/10.1128/JVI.01580-15Subjects
Fish ranavirus; Pathogens; Virulence; Biología y Biomedicina / BiologíaRights
© 2015, American Society for MicrobiologyAbstract
Amphibian-like ranaviruses include pathogens of fish, amphibians, and reptiles that have recently evolved from a fish-infecting
ancestor. The molecular determinants of host range and virulence in this group are largely unknown, and currently fish infection
models are lacking. We show that European sheatfish virus (ESV) can productively infect zebrafish, causing a lethal pathology,
and describe a method for the generation of recombinant ESV, establishing a useful model for the study of fish ranavirus
infections
Files in this item
Google Scholar:Martín, Verónica
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Mavian, Carla Nartuhi
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López Bueno, Alberto
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de Molina, Antonio
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Díaz, Eduardo
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Andrés, Germán
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Alcami, Antonio
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Alejo, Alí
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