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Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt(ii) complexes

dc.contributor.authorMedrano, Angeles
dc.contributor.authorDennis, Stephen M.
dc.contributor.authorÁlvarez-Valdés Olaguibel, María Desamparados 
dc.contributor.authorPerles, Josefina
dc.contributor.authorMcGregor Mason, Tracey
dc.contributor.authorGómez Quiroga, Adoración 
dc.contributor.otherUAM. Departamento de Química Inorgánicaes_ES
dc.date.accessioned2016-09-12T16:24:01Z
dc.date.available2016-09-12T16:24:01Z
dc.date.issued2015-02-28
dc.identifier.citationDalton Transactions 44.8 (2015): 3557-3562en_US
dc.identifier.issn1477-9226 (print)es_ES
dc.identifier.issn1477-9234 (online)es_ES
dc.identifier.urihttp://hdl.handle.net/10486/672905
dc.description.abstractPlatinum complexes, bearing aliphatic amines and phosphine ligands in trans configuration with iodide as leaving groups, are synthesized and characterized. The crystal structure of trans-PtI2(isopropylamine)(PPh3) is reported. The complex bearing isopropylamine is demonstrated to be the best candidate as its cytotoxic activity is comparable to or better than cisplatin. A remarkably higher interaction of the complexes with DNA is reported as compared to the parent chlorido series. Cell cycle studies of the complexes in six human cell lines are performed and also compared with the previous seriesen_US
dc.description.sponsorshipThe Spanish Ministerio de Economia y Competitividad has supported this work with the grant: SAF2012-34424. This work was also supported by a School of the Sciences, Stevenson University Seed Granten_US
dc.format.extent6 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofDalton Transactionsen_US
dc.rights© The Royal Society of Chemistry 2015en_US
dc.subject.otherCell cultureen_US
dc.subject.otherComplexationen_US
dc.subject.otherCrystal structureen_US
dc.subject.otherCytotoxicityen_US
dc.subject.otherLigandsen_US
dc.subject.otherPhosphorus compoundsen_US
dc.subject.otherPlatinumen_US
dc.subject.otherPlatinum compoundsen_US
dc.titleSynthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt(ii) complexesen_US
dc.typearticleen
dc.subject.ecienciaQuímicaes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1039/c4dt02392ges_ES
dc.identifier.doi10.1039/c4dt02392ges_ES
dc.identifier.publicationfirstpage3557es_ES
dc.identifier.publicationissue8es_ES
dc.identifier.publicationlastpage3562es_ES
dc.identifier.publicationvolume44es_ES
dc.relation.projectIDGobierno de España. SAF2012-34424es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.accessRightsopenAccessen
dc.authorUAMPerles Hernáez, Josefina (281166)
dc.facultadUAMFacultad de Ciencias


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