Neodymium-Based Stoichiometric Ultrasmall Nanoparticles for Multifunctional Deep-Tissue Photothermal Therapy
Entity
UAM. Departamento de Física de MaterialesPublisher
Wiley-VCH VerlagDate
2016-05-01Citation
10.1002/adom.201500726
Advanced Optical Materials 4.5 (2016): 782-789
ISSN
2195-1071DOI
10.1002/adom.201500726Funded by
This project has been supported by the Spanish Ministerio de Economía y Competitividad under project and MAT2013-47395-C4-1-R. B. del Rosal thanks Universidad Autónoma de Madrid for an FPI grant. Dragana Jovanović and Miroslav Dramićanin acknowledge financial support of the Ministry of Education, Science and Technological development of the Republic of Serbia (grant number 45020). Goran Dražić acknowledges the financial support of the Slovenian Research Agency (ARRS) through program no. P2-0148 and project J2-6754. Authors thanks COST action CM1403Project
Gobierno de España. MAT2013-47395-C4-1-REditor's Version
http://dx.doi.org/10.1002/adom.201500726Subjects
Rare earth nanoparticles; Photothermal therapy; Fluorescence imaging; Ultrasmall nanoparticles; FísicaRights
© 2016 John Wiley & Sons, Inc.Abstract
Nanoparticle-mediated photothermal therapy (NP-PTT) constitutes a flexible, highly selective, cost effective, and accurate tool for cancer treatment alone or in combination with other therapies such as radiotherapy or chemotherapy. The future application of NP-PTT in real life mainly depends on the design and synthesis of novel multifunctional nanoparticles that could overcome the current limitations of NP-PTT such as limited penetration depth and absence of therapy control. In this work, ultrasmall (≈2.4 nm) NdVO4 stoichiometric (100% constituent Nd3+ ions) nanoparticles are reported, which are capable of in vivo sub-tissue localized heating under 808 nm optical excitation while providing, simultaneously, the possibility of high penetration near-infrared fluorescence imaging. Ultrasmall stoichiometric NdVO4nanoparticles have evidenced a superior light-to-heat conversion efficiency. This is explained in terms of their large absorption cross-section at 808 nm (consequence of the particular spectroscopic properties of neodymium ions in NdVO4 and of the high neodymium content) as well as to their ultrasmall size that leads to large nonradiative decay rates. Results included in this work introduce ultrasmall, NdVO4 stoichiometric nanoparticles to the scientific community as multifunctional photothermal agents that could be considered as an alternative to traditional systems such as metallic, organic, or carbon-based nanoparticles
Files in this item
Google Scholar:Pérez-Delgado, Alberto
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Carrasco, Elisa
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Dražić, Goran
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Juarranz de la Fuente, Ángeles
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Sanz Rodríguez, Francisco
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Jaque García, Daniel
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Del Rosal, Blanca
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Jovanović, Dragana
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Dramićanin, Miroslav
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