T-regulatory cells and vascular function: the importance of their immunosuppressive action in hypertensive disease
Entity
UAM. Departamento de FarmacologíaPublisher
Lippincott, Williams & WilkinsDate
2016-01-01Citation
10.1097/HJH.0000000000000784
Journal of Hypertension 34.1 (2016): 36-38
ISSN
0263-6352 (print); 1473-5598 (online)DOI
10.1097/HJH.0000000000000784Funded by
MG is supported by the Sara Borrell Program (CD12/00589). MS and MG have received research grants from MINECO (SAF2012-36400) and from ISCIII (RD12/0042/0024) and (RD12/0042/0053).Project
Gobierno de España. SAF2012-36400Editor's Version
http://dx.doi.org/10.1097/HJH.0000000000000784Subjects
Arterial blood pressure; Tregs; FarmaciaAbstract
INTRODUCTION:
Reliable predictors of poor clinical outcome despite successful revascularization might help select patients with acute ischemic stroke for thrombectomy. We sought to determine whether baseline Alberta Stroke Program Early CT Score (ASPECTS) applied to CT angiography source images (CTA-SI) is useful in predicting futile recanalization.
METHODS:
Data are from the FUN-TPA study registry (ClinicalTrials.gov; NCT02164357) including patients with acute ischemic stroke due to proximal arterial occlusion in anterior circulation, undergoing reperfusion therapies. Baseline non-contrast CT and CTA-SI-ASPECTS, time-lapse to image acquisition, occurrence, and timing of recanalization were recorded. Outcome measures were NIHSS at 24 h, symptomatic intracranial hemorrhage, modified Rankin scale score, and mortality at 90 days. Futile recanalization was defined when successful recanalization was associated with poor functional outcome (death or disability).
RESULTS:
Included were 110 patients, baseline NIHSS 17 (IQR 12; 20), treated with intravenous thrombolysis (IVT; 45 %), primary mechanical thrombectomy (MT; 16 %), or combined IVT + MT (39 %). Recanalization rate was 71 %, median delay of 287 min (225; 357). Recanalization was futile in 28 % of cases. In an adjusted model, baseline CTA-SI-ASPECTS was inversely related to the odds of futile recanalization (OR 0.5; 95 % CI 0.3-0.7), whereas NCCT-ASPECTS was not (OR 0.8; 95 % CI 0.5-1.2). A score ≤5 in CTA-SI-ASPECTS was the best cut-off to predict futile recanalization (sensitivity 35 %; specificity 97 %; positive predictive value 86 %; negative predictive value 77 %).
CONCLUSIONS:
CTA-SI-ASPECTS strongly predicts futile recanalization and could be a valuable tool for treatment decisions regarding the indication of revascularization therapies
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Google Scholar:Galán, María
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Salaices Sánchez, Mercedes
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