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dc.contributor.authorAndradas, Clara
dc.contributor.authorBlasco-Benito, Sandra
dc.contributor.authorCastillo-Lluva, Sonia
dc.contributor.authorDillenburg- Pilla, Patricia
dc.contributor.authorDiez-Alarcia, Rebeca
dc.contributor.authorJuanes-García, Alba
dc.contributor.authorGarcía-Taboada, Elena
dc.contributor.authorHernando-Llorente, Rodrigo
dc.contributor.authorSoriano, Joaquim
dc.contributor.authorHamann, Sigrid
dc.contributor.authorWenners, Antonia
dc.contributor.authorAlkatout, Ibrahim
dc.contributor.authorKlapper, Wolfram
dc.contributor.authorRocken, Christoph
dc.contributor.authorBauer, Maret
dc.contributor.authorArnold, Norbert
dc.contributor.authorQuintanilla, Miguel
dc.contributor.authorMegías, Diego
dc.contributor.authorVicente-Manzanares, Miguel
dc.contributor.authorUrigüen, Leyre
dc.contributor.authorGutkind, J. Silvio
dc.contributor.authorGuzmán, Manuel
dc.contributor.authorPérez-Gómez, Eduardo
dc.contributor.authorSánchez, Cristina
dc.contributor.otherUAM. Departamento de Medicinaes_ES
dc.contributor.otherInstituto de Investigaciones Biomédicas "Alberto Sols" (IIBM)es_ES
dc.date.accessioned2017-01-25T15:33:01Z
dc.date.available2017-01-25T15:33:01Z
dc.date.issued2016-06-21
dc.identifier.citationOncotarget 7.30 (2016): 46565-47575en
dc.identifier.issn1949-2553es_ES
dc.identifier.urihttp://hdl.handle.net/10486/676576
dc.description.abstractThe orphan G protein-coupled receptor GPR55 has been directly or indirectly related to basic alterations that drive malignant growth: uncontrolled cancer cell proliferation, sustained angiogenesis, and cancer cell adhesion and migration. However, little is known about the involvement of this receptor in metastasis. Here, we show that elevated GPR55 expression in human tumors is associated with the aggressive basal/triple-negative breast cancer population, higher probability to develop metastases, and therefore poor patient prognosis. Activation of GPR55 by its proposed endogenous ligand lysophosphatidylinositol confers pro-invasive features on breast cancer cells both in vitro and in vivo. Specifically, this effect is elicited by coupling to Gq/11 heterotrimeric proteins and the subsequent activation, through ERK, of the transcription factor ETV4/PEA3. Together, these data show that GPR55 promotes breast cancer metastasis, and supports the notion that this orphan receptor may constitute a new therapeutic target and potential biomarker in the highly aggressive triple-negative subtypeen_US
dc.description.sponsorshipThis work was supported by grants from Spanish Ministry of Economy and Competitiveness [PI11/00295 to CS, PI14/01101 to CS and EP-G, SAF2013-46183-R to MQ, and SAF2014-54705-R to MV-M, supported with European Regional Development (FEDER) funds] and Madrid Regional Government (S2010/BMD-2308 to MG, and 2010/BMD-2359 to MQ). EPG was a recipient of a Postdoctoral Research Contract from Fundación Científica Asociación Española Contra el Cáncer and a Federation of the Societies of Biochemistry and Molecular Biology (FEBS) Short-term Fellowship. SB-B and SC-L are recipients of a Formación de Profesorado Universitario (FPU) fellowship and a Ramón y Cajal research contract, respectively, from the Spanish Ministry of Economy and Competitivenessen_US
dc.format.extent11 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherImpact Journalsen_US
dc.relation.ispartofOncotargeten_US
dc.subject.otherGPR55en_US
dc.subject.otherG protein-coupled receptoren_US
dc.subject.otherCannabinoidsen_US
dc.subject.otherMetastasisen_US
dc.subject.otherTriple-negative breast canceren_US
dc.titleActivation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast canceren_US
dc.typearticleen
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttp://dx.doi.org/ 10.18632/oncotarget.10206es_ES
dc.identifier.doi10.18632/oncotarget.10206es_ES
dc.identifier.publicationfirstpage46565es_ES
dc.identifier.publicationissue30es_ES
dc.identifier.publicationlastpage47575es_ES
dc.identifier.publicationvolume7es_ES
dc.relation.projectIDGobierno de España. PI11/00295es_ES
dc.relation.projectIDGobierno de España. PI14/01101es_ES
dc.relation.projectIDGobierno de España. SAF2013-46183-Res_ES
dc.relation.projectIDGobierno de España. SAF2014-54705-Res_ES
dc.relation.projectIDComunidad de Madrid. S2010/BMD-2308/CANNAB-CMes_ES
dc.relation.projectIDComunidad de Madrid. 2010/ BMD-2359/ SKINMODELes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimientoes_ES
dc.rights.accessRightsopenAccessen
dc.facultadUAMFacultad de Medicina


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