dc.contributor.author | Argente-Arizón, Pilar | |
dc.contributor.author | Ros Pérez, Purificación | |
dc.contributor.author | Díaz, Francisca | |
dc.contributor.author | Fuente-Martin, Esther | |
dc.contributor.author | Castro-González, David | |
dc.contributor.author | Sánchez-Garrido, Miguel Ángel | |
dc.contributor.author | Barrios, Vicente | |
dc.contributor.author | Tena-Sempere, Manuel | |
dc.contributor.author | Argente Oliver, Jesús | |
dc.contributor.author | Chowen, Julie Ann | |
dc.contributor.other | UAM. Departamento de Pediatría | es_ES |
dc.date.accessioned | 2017-01-25T16:02:48Z | |
dc.date.available | 2017-01-25T16:02:48Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Biology of Sex Differences 7.26 (2016): 1-17 | en_US |
dc.identifier.issn | 2042-6410 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/676581 | |
dc.description.abstract | Background: Males and females respond differently to diverse metabolic situations. Being raised in a small litter is
reported to cause overnutrition that increases weight gain and predisposes an individual to metabolic disturbances
in adulthood; however, existing data are inconsistent. Indeed, significant weight gain and/or metabolic disturbances, such
as hyperinsulinemia and hyperleptinemia, are sometimes not encountered. We hypothesized that these inconsistencies
could be due to the animal’s sex and/or age at which metabolic parameters are measured.
Methods: To analyze the effects of neonatal overnutrition, male and female Wistar rats were raised in litters of 4 or 12
pups/dam and killed at postnatal days (PND) 10, 21, 30, 50, 85, or 150. In a second study to determine if neonatal sex
steroid levels influence sex differences in metabolic parameters, female rats were treated with testosterone on PND1.
Effects on weight, length, fat pads, adipokine production, and serum levels of glucose, metabolic hormones, and
cytokines were analyzed in both studies.
Results: By PND10, both males and females raised in small litters had increased body weight, body length, adiposity, and
serum glucose, insulin, leptin, and adiponectin levels. Females had a greater increase in inguinal fat, and males had higher
expression of leptin messenger RNA (mRNA) and serum insulin, as well as increased testosterone levels. Most of the litter
size effects diminished or disappeared after weaning and reappeared during adulthood in males, with sex differences in
body size and adiposity being apparent postpubertally. Treatment of females with testosterone on PND1 tended to
masculinize some metabolic parameters in adulthood such as increased body weight and serum leptin levels.
Conclusions: Our results indicate that (1) both sex and age determine the response to neonatal overnutrition; (2)
differences in neonatal sex steroid levels may participate in the development of sex differences in metabolic parameters
in adulthood and possibly in the response to neonatal overnutrition; and (3) the comparison of circulating hormone and
cytokine levels, even in normal control animals, should take into consideration the early neonatal nutritional environment | en_US |
dc.description.sponsorship | This work was supported by the Ministerio de Ciencia e Innovación Grants
(BFU2011–27492 and BFU2014-51836-C2-2-R (to JAC); BFI2011-25021 (to MTS))
and Fondo de Investigación Sanitaria (PI13/02195 to JA) co-funded by European
FEDER Program, Junta de Andalucia, Spain (Project FQM12-1943 to MTS) and
Centro de Investigación Biomédica en Red Fisiopatología de Obesidad y Nutrición
(JA and MTS) of the Instituto de Salud Carlos III, and Fundación de Endocrinología
y Nutrición | en_US |
dc.format.extent | 17 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | BioMed Central | en_US |
dc.relation.ispartof | Biology of Sex Differences | en_US |
dc.rights | © 2016 Argente-Arizón et al. | es_ES |
dc.subject.other | Neonatal nutrition | en_US |
dc.subject.other | Metabolic hormones | en_US |
dc.subject.other | Sex differences | en_US |
dc.subject.other | Litter size | en_US |
dc.subject.other | Neonatal testosterone | en_US |
dc.title | Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1186/s13293-016-0079-5 | es_ES |
dc.identifier.doi | 10.1186/s13293-016-0079-5 | es_ES |
dc.identifier.publicationfirstpage | 1 | es_ES |
dc.identifier.publicationissue | 26 | es_ES |
dc.identifier.publicationlastpage | 17 | es_ES |
dc.identifier.publicationvolume | 7 | es_ES |
dc.relation.projectID | Gobierno de España. BFU2011–27492 | es_ES |
dc.relation.projectID | Gobierno de España. BFU2014-51836-C2-2-R | es_ES |
dc.relation.projectID | Gobierno de España. BFI2011-25021 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | Argente Oliver, Jesús (100008) | |
dc.authorUAM | Chowen , Julie Ann (268961) | |
dc.authorUAM | Ros Pérez, Purificación (262091) | |
dc.facultadUAM | Facultad de Medicina | |