Generation of a human iPSC line from a patient with a defect of intergenomic communication

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Show simple item record Zurita, Francisco Galera, Teresa González-Páramos, Cristina Moreno-Izquierdo, Ana Schneiderat, Peter Fraga, Mario F. Fernández, Agustin F. Garesse, Rafael Gallardo, M. Esther
dc.contributor.other UAM. Departamento de Bioquímica es_ES
dc.contributor.other Instituto de Investigaciones Biomédicas "Alberto Sols" (IIBM) es_ES 2017-03-31T11:08:07Z 2017-03-31T11:08:07Z 2016-01-01
dc.identifier.citation Stem Cell Research 16 (2016): 120-123 en_US
dc.identifier.issn 1873-5061 es_ES
dc.description.abstract Human iPSC line PG64SV.2 was generated from fibroblasts of a patient with a defect of intergenomic communication. This patient harbored a homozygous mutation (c.2243G>C; p.Trp748Ser) in the gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma gene (POLG). Reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non integrative methodology that involves the use of Sendai virus. en_US
dc.description.sponsorship This work was supported by grants from the “Centro de Investigación Biomédica en Red en enfermedades raras” (CIBERER) (Grant 13-717/132.05 to RG), the “Instituto de Salud Carlos III” [Fondo de Investigación Sanitaria and Regional development fund (ERDF/FEDER) funds PI10/0703 and PI13/00556 to RG and PI15/00484 to MEG], “Comunidad Autónoma de Madrid” (Grant number S2010/BMD-2402 to RG); TG receives grant support from the Universidad Autónoma de Madrid (FPI-UAM) and FZD from the Ministerio de Educación, Cultura y Deporte (Grant FPU13/00544). MEG is staff scientist at the “Centro de Investigación Biomédica en Red en Enfermedades Raras” (CIBERER) en_US
dc.format.extent 4 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Elsevier B.V. es_ES
dc.relation.ispartof Stem Cell Research en_US
dc.rights © 2015 The Authors en_US
dc.subject.other IPSC line en_US
dc.subject.other PG64SV.2 en_US
dc.subject.other Mutation (c.2243GNC; p.Trp748Ser) en_US
dc.subject.other Gene (POLG) en_US
dc.subject.other Sendai virus en_US
dc.title Generation of a human iPSC line from a patient with a defect of intergenomic communication en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion es_ES
dc.identifier.doi 10.1016/j.scr.2015.12.016 es_ES
dc.identifier.publicationfirstpage 120 es_ES
dc.identifier.publicationissue 16 es_ES
dc.identifier.publicationlastpage 123 es_ES
dc.relation.projectID Comunidad de Madrid. S2010/BMD-2402 MITOLAB-CM es_ES
dc.relation.projectID Gobierno de España. FPU13/00544 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en Reconocimiento – NoComercial – SinObraDerivada es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Garesse Alarcón, Rafael (259828)

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