Plasma levels of monocyte chemoattractant protein-1, n-terminal fragment of brain natriuretic peptide and calcidiol are independently associated with the complexity of coronary artery disease
Autor (es)
Martin-Reyes, Roberto; Franco-Peláez, Juan Antonio; Lorenzo, Scar; González-Casaus, María Luisa; Pello, Ana María; Aceña Navarro, Álvaro


Entidad
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Editor
Public Library of ScienceFecha de edición
2016-05-01Cita
10.1371/journal.pone.0152816
PLoS ONE 11.5 (2016): e0152816
ISSN
1932-6203DOI
10.1371/journal.pone.0152816Financiado por
This work was supported by grants from Fondo de Investigaciones Sanitarias [PI14/1567, PI14/00386, PIE13/00051], Spanish Society of Cardiology; Spanish Heart Foundation; Instituto de Salud Carlos III FEDER [FJD biobank grant RD09/0076/00101]; and AbbVie LaboratoriesVersión del editor
http://dx.doi.org/10.1371/journal.pone.0152816Materias
Syntax Score; Coronary artery calcification; Cardiovascular damage; Metabolism; MCP-1; NT-proBNP; MedicinaDerechos
© 2016 Martín-Reyes et al.Resumen
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background and Objectives We investigated the relationship of the Syntax Score (SS) and coronary artery calcification (CAC), with plasma levels of biomarkers related to cardiovascular damage and mineral metabolism, as there is sparse information in this field. Methods We studied 270 patients with coronary disease that had an acute coronary syndrome (ACS) six months before. Calcidiol, fibroblast growth factor-23, parathormone, phosphate and monocyte chemoattractant protein-1 [MCP-1], high-sensitivity C-reactive protein, galectin-3, and N-terminal pro-brain natriuretic peptide [NT-proBNP] levels, among other biomarkers, were determined. CAC was assessed by coronary angiogram as low-grade (0-1) and high-grade (2-3) calcification, measured with a semiquantitative scale ranging from 0 (none) to 3 (severe). For the SS study patients were divided in SS<14 and SS14. Multivariate linear and logistic regression analyses were performed. Results MCP-1 predicted independently the SS (RC = 1.73 [95%CI = 0.08-3.39]; p = 0.040), along with NT-proBNP (RC = 0.17 [95%CI = 0.05-0.28]; p = 0.004), male sex (RC = 4.15 [95%CI = 1.47-6.83]; p = 0.003), age (RC = 0.13 [95%CI = 0.02-0.24]; p = 0.020), hypertension (RC = 3.64, [95%CI = 0.77-6.50]; p = 0.013), hyperlipidemia (RC = 2.78, [95%CI = 0.28-5.29]; p = 0.030), and statins (RC = 6.12 [95%CI = 1.28-10.96]; p = 0.013). Low calcidiol predicted high-grade calcification independently (OR = 0.57 [95% CI = 0.36-0.90]; p = 0.013) along with ST-elevation myocardial infarction (OR = 0.38 [95%CI = 0.19-0.78]; p = 0.006), diabetes (OR = 2.35 [95%CI = 1.11-4.98]; p = 0.028) and age (OR = 1.37 [95%CI = 1.18-1.59]; p<0.001). During follow-up (1.79 [0.94-2.86] years), 27 patients developed ACS, stroke, or transient ischemic attack. A combined score using SS and CAC predicted independently the development of the outcome.Conclusions MCP-1 and NT-proBNP are independent predictors of SS, while low calcidiol plasma levels are associated with CAC. More studies are needed to confirm these data.
Lista de ficheros
Google Scholar:Martin-Reyes, Roberto
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Franco-Peláez, Juan Antonio
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Lorenzo, Scar
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González-Casaus, María Luisa
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Pello, Ana María
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Aceña Navarro, Álvaro
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Carda, Rocío
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Martín Ventura, José Luis
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Blanco-Colio, Luis
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Martín-Mariscal, María Luisa
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Martínez-Milla, Juan
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Villa-Bellosta, Ricardo
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Piñero, Antonio
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Navarro, Felipe
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Egido, Jesús
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Tuñón Fernández, José Luis
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