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Urinary Kininogen-1 and Retinol binding protein-4 respond to Acute Kidney Injury: Predictors of patient prognosis?

Author
Gonzalez-Calero, Laura; Martin-Lorenzo, Marta; Ramos-Barron, Angeles; Ruiz-Criado, Jorge; Maroto, Aroa S.; Ortiz, Alberto; Gomez-Alamillo, Carlos; Arias, Manuel; Vivanco, Fernando
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)
Publisher
Nature Publishing Group
Date
2016-01-21
Citation
10.1038/srep19667
Scientific Reports 6 (2016): 19667
 
 
 
ISSN
2045-2322
DOI
10.1038/srep19667
Funded by
Funding: from Instituto de Salud Carlos III: FIS PI11/01401, PI13/01873, FIS IF08/3667-1, CP09/00229, PI13/00047, PI10/00624, ISCIII-RETIC REDinREN RD012/0021. FEDER funds, Comunidad de Madrid/CIFRA S2010/BMD-2378, Programa Intensificación Actividad Investigadora (ISCIII/Agencia Laín-Entralgo/CM) to AO, IDCSalud (3371/002) and Fundación Conchita Rábago de Jiménez Díaz, Proteomic Facility from Universidad Complutense de Madrid-Fundación Parque Científico de Madrid (UCM-FPCM), Spain, a member of ProteoRed-ISCIII Network member of ProteoRed- ISCIII Network
Project
Comunidad de Madrid. S2010/BMD-2378/CIFRA
Editor's Version
http://dx.doi.org/10.1038/srep19667
Subjects
Therapy; Creatinine; Molecules in urine; Urinary proteome; Kininogen-1; RBP4; Medicina
URI
http://hdl.handle.net/10486/677997

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

Implementation of therapy for acute kidney injury (AKI) depends on successful prediction of individual patient prognosis. Clinical markers as serum creatinine (sCr) have limitations in sensitivity and early response. The aim of the study was to identify novel molecules in urine which show altered levels in response to AKI and investigate their value as predictors of recovery. Changes in the urinary proteome were here investigated in a cohort of 88 subjects (55 AKI patients and 33 healthy donors) grouped in discovery and validation independent cohorts. Patients'urine was collected at three time points: within the first 48 h after diagnosis(T1), at 7 days of follow-up(T2) and at discharge of Nephrology(T3). Differential gel electrophoresis was performed and data were confirmed by Western blot (WB), liquid chromatography/mass spectrometry (LC-MS/MS) and enzyme-linked immunosorbent assay (ELISA). Retinol binding protein 4 (RBP4) and kininogen-1 (KNG1) were found significantly altered following AKI. RBP4 increased at T1, and progressively decreased towards normalization. Maintained decrease was observed for KNG1 from T1. Individual patient response along time revealed RBP4 responds to recovery earlier than sCr. In conclusion, KNG1 and RBP4 respond to AKI. By monitoring RBP4, patient's recovery can be anticipated pointing to a role of RBP4 in prognosis evaluation.
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Google™ Scholar:Gonzalez-Calero, Laura - Martin-Lorenzo, Marta - Ramos-Barron, Angeles - Ruiz-Criado, Jorge - Maroto, Aroa S. - Ortiz, Alberto - Gomez-Alamillo, Carlos - Arias, Manuel - Vivanco, Fernando

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  • Producción científica en acceso abierto de la UAM [15094]

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