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dc.contributor.authorTorralba, Daniel
dc.contributor.authorBaixauli, Frances
dc.contributor.authorSánchez Madrid, Francisco 
dc.contributor.otherUAM. Departamento de Medicinaes_ES
dc.contributor.otherInstituto de Investigación del Hospital de La Princesa (IP)es_ES
dc.date.accessioned2017-04-26T14:47:54Z
dc.date.available2017-04-26T14:47:54Z
dc.date.issued2016-09-28
dc.identifier.citationFrontiers in Cell an Developmental Biology 4 (2016): Article 107en_US
dc.identifier.issn2296-634Xes_ES
dc.identifier.urihttp://hdl.handle.net/10486/678035
dc.description.abstractMitochondria regulate multiple cell processes, including calcium signaling, apoptosis and cell metabolism. Mitochondria contain their own circular genome encoding selected subunits of the oxidative phosphorylation complexes. Recent findings reveal that, in addition to being maternally inherited, mitochondria can traverse cell boundaries and thus be horizontally transferred between cells. Although, the physiological relevance of this phenomenon is still under debate, mitochondria uptake rescues mitochondrial respiration defects in recipient cells and regulates signaling, proliferation or chemotherapy resistance in vitro and in vivo. In this review, we outline the pathophysiological consequences of horizontal mitochondrial transfer and offer a perspective on the cellular and molecular mechanisms mediating their intercellular transmission, including tunneling nanotubes, extracellular vesicles, cellular fusion, and GAP junctions. The physiological relevance of mitochondrial transfer and the potential therapeutic application of this exchange for treating mitochondrial-related diseases are discusseden_US
dc.description.sponsorshipThis study was supported by grants SAF2014-55579-R from the Spanish Ministry of Economy and Competitiveness, INDISNET-S2011/BMD-2332 from the Comunidad de Madrid, ERC-2011-AdG 294340-GENTRIS, Red Cardiovascular RD 12-0042-0056 and grant PIE13/00041 BIOIMID from Instituto Salud Carlos III (ISCIII)en_US
dc.format.extent11 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherFrontiers Research Foundationen_US
dc.relation.ispartofFrontiers in Cell an Developmental Biologyen_US
dc.rights© 2016 Torralba, Baixauli and Sánchez-Madrid.es_ES
dc.subject.otherHorizontal genetic transferen_US
dc.subject.otherTunneling nanotubesen_US
dc.subject.otherMitochondrial diseasesen_US
dc.subject.otherExtracellular vesiclesen_US
dc.subject.otherInflammationen_US
dc.subject.otherDAMPsen_US
dc.subject.otherExosomesen_US
dc.subject.otherCommunicationen_US
dc.titleMitochondria know no boundaries: Mechanisms and functions of intercellular mitochondrial transferen_US
dc.typearticleen
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3389/fcell.2016.00107es_ES
dc.identifier.doi10.3389/fcell.2016.00107es_ES
dc.identifier.publicationfirstpage107-1es_ES
dc.identifier.publicationlastpage107-11es_ES
dc.identifier.publicationvolume4es_ES
dc.relation.projectIDGobierno de España. SAF2014-55579-Res_ES
dc.relation.projectIDComunidad de Madrid. S2011/BMD-2332/INDISNETes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimiento
dc.rights.accessRightsopenAccessen
dc.authorUAMSánchez Madrid, Francisco (259404)
dc.facultadUAMFacultad de Medicina
dc.institutoUAMInstituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-Princesa)


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