Leptin concentration and risk of impaired physical function in older adults: the Seniors-ENRICA cohort
Entity
UAM. Departamento de Medicina Preventiva y Salud Pública y MicrobiologíaPublisher
Oxford University PressDate
2016-11-06Citation
10.1093/ageing/afw142
Age and ageing 45.6 (2016): 819-826
ISSN
0002-0729 (print); 1468-2834 (online)DOI
10.1093/ageing/afw142Funded by
This work was supported by FIS grants 12/1166 and 13/0288 (Instituto de Salud Carlos III, State Secretary of R+D+I, and FEDER/FSE), the CIBERESP, the FRAILOMIC Initiative (FP7-HEALTH-2012-Proposal no. 305483-2) and the ATHLOS project (EU H2020- Project ID: 635316)Project
info:eu-repo/grantAgreement/EC/FP7/305483-2; info:eu-repo/grantAgreement/EC/H2020/635316/EU//ATHLOSEditor's Version
http://dx.doi.org/10.1093/ageing/afw142Subjects
aged; mobility limitation; physical fitness; leptin; biological markers; prospective studies; MedicinaNote
This is a pre-copyedited, author-produced PDF of an article accepted for publication in Age and Ageing following peer review. The version of record Alberto Lana, Ellen Struijk, Pilar Guallar-Castillón, Jose María Martín-Moreno, Fernando Rodríguez Artalejo, Esther Lopez-Garcia; Leptin concentration and risk of impaired physical function in older adults: the Seniors-ENRICA cohort. Age Ageing 45.6 (2016): 819-826 is available online at: http://dx.doi.org/ 10.1093/ageing/afw142Rights
© The Author 2016Abstract
Leptin resistance, which may develop during the aging process, stimulates the production of proinflammatory cytokines and insulin resistance that could impair the muscle function. However, the role of leptin on physical functioning among older adults has not yet been elucidated.
Objective: To examine the association between serum leptin levels and physical function impairment in older adults.
Design and setting: Prospective study of 1,556 individuals aged ≥60 years from the Seniors-ENRICA cohort, who were free of physical function limitation at baseline.
Main outcome measure: Serum leptin was measured in 2008-2010, and incident functional limitation was assessed through 2012. Self-reported limitations in agility and mobility were assessed with the Rosow and Breslau scale, limitation in the lower extremity function was measured with the Short Physical Performance Battery, and impairment in the overall physical performance with the physical component summary of the SF-12.
Results: After adjustment for potential confounders, and compared to individuals in the lowest quartile of leptin concentration, those in the highest quartile showed increased risk of impaired physical function; the odds ratio (95% confidence interval) and p-trend was: 1.95 (1.11-3.43), p=0.006 for self-reported impaired mobility; 1.76 (1.08-2.87), p=0.02 for self-reported impaired agility; 1.48 (1.02-2.15), p=0.04 for limitation in the lower extremity function; and 1.97 (1.20-3.22), p=0.01 for decreased overall physical performance. These associations were only modestly explained by C-reactive protein and insulin resistance. Moreover, the associations held across groups with varying health status and were independent of estimated total body fat.
Conclusions: Higher leptin concentration was associated with increased risk of impaired physical function. Preserving metabolic function during the old age could help delaying physical function decline
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Google Scholar:Lana, Alberto
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Struijk, Ellen A.
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Guallar Castillón, María Pilar
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Martín-Moreno, José M.
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Rodríguez Artalejo, Fernando
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López García, Esther
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