Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats
Entity
UAM. Departamento de FisiologíaPublisher
Public Library of ScienceDate
2017-10-02Citation
10.1371/journal.pone.0185805
PLoS ONE 12.10 (2017): e0185805
ISSN
1932-6203DOI
10.1371/journal.pone.0185805Funded by
This study was supported by fellowships (to DMV and to MMR) from the CONACyT (Mexico) and grants (to MF) from Comunidad de Madrid (S2013/ABI 2783, ªINSPIRA1-CMº) and Fondo Europeo de Desarrollo RegionalProject
Comunidad de Madrid. S2013/ABI 2783/INSPIRA 1Editor's Version
https://doi.org/10.1371/journal.pone.0185805Subjects
Testosterone; Cholesterol oxidation products (COPs); Dosahexaenoic acid (DHA); Orchidectomized; Formation of COPs in arteries; MedicinaRights
© 2017 Villalpando et al.Abstract
Testosterone deficiency has been correlated with increased cardiovascular diseases, which in turn has been associated with increased oxidative stress. Several studies have considered cholesterol oxidation products (COPs) as oxidative stress biomarkers, since some of them play pro-oxidant and pro-inflammatory roles. We have previously described the cardioprotective effects of a dosahexaenoic acid (DHA) supplemented diet on the aortic and mesenteric artery function of orchidectomized rats. The aim of this study was to investigate whether impaired gonadal function alters the formation of COPs, as well as the potential preventive role of a DHA-supplemented diet on that effect. For this purpose, aortic and mesenteric artery segments obtained from control and orchidectomized rats, fed with a standard or supplemented with DHA, were used. The content of the following COPs: 7α-hydroxycholes-terol, 7β-hydroxycholesterol, 7-ketocholesterol, 5,6α-epoxycholesterol, 5,6β-epoxycholes-terol, cholestanetriol and 25-hydroxycholesterol, were analyzed by gas chromatography. The results showed that orchidectomy increased the formation of COPs in arteries from orchidectomized rats, which may participate in the orchidectomy-induced structural and functional vascular alterations already reported. The fact that the DHA-supplemented diet prevented the orchidectomy-induced COPs increase confirms the cardiovascular protective actions of DHA, which could be of special relevance in mesenteric arterial bed, since it importantly controls the systemic vascular resistanc
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Google Scholar:Villalpando, Diva M.
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Rojas, Mibsam M.
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García, Hugo S.
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Ferrer Parra, Mercedes
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