dc.contributor.author | Provencio Pulla, Mariano | |
dc.contributor.author | Rodríguez, Marta | |
dc.contributor.author | Cantos, Blanca | |
dc.contributor.author | Sabín, Pilar | |
dc.contributor.author | Quero, Cristina | |
dc.contributor.author | García-Arroyo, Francisco R. | |
dc.contributor.author | Rueda, Antonio | |
dc.contributor.author | Maximiano, Constanza | |
dc.contributor.author | Rodríguez-Abreu, Delvys | |
dc.contributor.author | Sánchez, Antonio | |
dc.contributor.author | Silva, Javier | |
dc.contributor.author | García, Vanesa | |
dc.contributor.author | GOTEL (Spanish Lymphoma Oncology Group) | |
dc.contributor.other | UAM. Departamento de Medicina | es_ES |
dc.date.accessioned | 2018-02-14T14:21:16Z | |
dc.date.available | 2018-02-14T14:21:16Z | |
dc.date.issued | 2017-03-22 | |
dc.identifier.citation | Oncotarget 8.31 (2017): 50949-50957 | en_US |
dc.identifier.issn | 1949-2553 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/681189 | |
dc.description.abstract | Purpose: To determine the feasibility of mRNAs (C-MYC, BCL-XL, BCL-6, NF-κβ,
PTEN and AKT) in exosomes of plasma as a liquid biopsy method for monitoring and
prognostic evolution in B-cell lymphomas.
Patients and Methods: Exosomes were isolated from 98 patients with B-cell
Lymphoma and 68 healthy controls. mRNAs were analyzed by quantitative PCR. An
additional 31 post-treatment samples were also studied.
Results: In the general and follicular lymphoma series, the presence of AKT
mRNA was associated with poor response to rituximab-based treatment. Patients
with first relapse or disease progression showed a lower percentage of PTEN and
BCL-XL mRNA. The presence of BCL-6 mRNA was associated with a high death rate.
The absence of PTEN mRNA in the general series, and presence of C-MYC mRNA in
follicular lymphomas, were associated with short progression-free survival. BCL-6 and
C-MYC mRNA were independent prognostic variables of overall survival. C-MYC mRNA
may provide prognostic information with respect to overall survival. BCL-XL mRNA
and increase of BCL-6 mRNA in post-treatment samples could serve as molecular
monitoring markers.
Conclusions: This is the first large study to evaluate the prognostic and predictive
values of pretreatment tumor-associated mRNA in exosomes. BCL-6 and C-MYC mRNA
positivity in pretreatment samples were predictors of worse PFS compared to patients
with mRNA negativity. C-MYC mRNA positivity was also a statistically significant
predictor of inability to obtain complete response with first-line therapy | en_US |
dc.description.sponsorship | This study was supported by grants FIS-PI08/0862, and SAF2010-20750. During this study, V. García received Fundación AECC and RTICC-RD2012/0036/0006 fellowships | en_US |
dc.format.extent | 9 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Impact Journals | en_US |
dc.relation.ispartof | Oncotarget | en_US |
dc.rights | © 2017 Provencio et al. | es_ES |
dc.subject.other | Exosomes | en_US |
dc.subject.other | mRNA | en_US |
dc.subject.other | Liquid biopsy | en_US |
dc.subject.other | B-cell lymphomas | en_US |
dc.subject.other | BCL-6 | en_US |
dc.title | mRNA in exosomas as a liquid biopsy in non-Hodgkin Lymphoma: a multicentric study by the Spanish Lymphoma Oncology Group | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | https://doi.org/10.18632/oncotarget.16435 | es_ES |
dc.identifier.doi | 10.18632/oncotarget.16435 | es_ES |
dc.identifier.publicationfirstpage | 50949 | es_ES |
dc.identifier.publicationissue | 31 | es_ES |
dc.identifier.publicationlastpage | 50957 | es_ES |
dc.identifier.publicationvolume | 8 | es_ES |
dc.relation.projectID | Gobierno de España. FIS-PI08/0862 | es_ES |
dc.relation.projectID | Gobierno de España. SAF2010-20750 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | Provencio Pulla, Mariano (262376) | |
dc.facultadUAM | Facultad de Medicina | |