Influence of dialysis membrane composition on plasma bisphenol A levels during online hemodiafiltration
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Publisher
Public Library of ScienceDate
2018-03-01Citation
10.1371/journal.pone.0193288
PLoS ONE 13.3 (2018): e0193288
ISSN
1932-6203DOI
10.1371/journal.pone.0193288Funded by
The Renal, Vascular and Diabetes Laboratory is funded by Ministerio de Economia, Industria y competitividad: FIS ISCIII FEDER funds PI16/01298, PI15/00298, PI16/02057, PI16/01900, SCIII-RETIC REDinREN RD12/0021 RD16/0009, CYTED IBERERC and Sociedad Madrileña de Nefrologia, Programa Intensificación Actividad Investigadora (ISCIII) to AO. This work was supported by a grant from Nipro corporation, and Fundacioón Renal Íñigo Álvarez de Toledo (FRIAT)Project
Gobierno de España. PI16/01298; Gobierno de España. PI15/00298; Gobierno de España. PI16/02057; Gobierno de España. PI16/01900; Gobierno de España. RD12/0021; Gobierno de España. RD16/0009Editor's Version
https://doi.org/10.1371/journal.pone.0193288Subjects
Bisphenol A; Online hemodiafiltration (OL-HDF); Dialysis membranes; MedicinaRights
© 2018 Mas et al.Abstract
Introduction: Bisphenol A (BPA) is an ubiquitous environmental toxin that is also found in dialyzers. Online hemodiafiltration (OL-HDF) more efficiently clears high molecular weight molecules, and this may improve BPA clearance. However, the BPA contents of dialysis membranes may be a source of BPA loading during OL-HDF. Methods A prospective study assessed plasma BPA levels in OL-HDF patients using BPA-free (polynephron) or BPA-containing (polysulfone) dialyzers in a crossover design with two arms, after a run-in OL-HDF period of at least 6 months with the same membrane: 31 patients on polynephron at baseline were switched to polysulfone membranes for 3 months (polynephron-to-polysulfone) and 29 patients on polysulfone were switched to polynephron for 3 months (polysulfone-to-polynephron). Results After a run-in OL-HDF period of at least 6 months with the same membrane, baseline predialysis BPA was lower in patients on polynephron (8.79±7.97 ng/ml) than in those on polysulfone (23.42±20.38 ng/mL, p < 0.01), but still higher than in healthy controls ( < 2 ng/mL). After 3 months of polynephron-to-polysulfone switch, BPA was unchanged (8.98±7.88 to 11.14±15.98 ng/mL, ns) while it decreased on the polysulfone-to-polynephron group (23.42±20.38 to 11.41±12.38 ng/mL, p < 0.01). Conclusion OL-HDF for 3 months with BPA-free dialyzer membranes was associated to a significant decrease in predialysis BPA levels when compared to baseline BPA levels while on a BPA-containing membrane
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Google Scholar:Mas, Sebastián
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Bosch-Panadero, Enrique
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Abaigar, Pedro
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Camarero, Vanesa
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Mahillo, Ignacio
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Civantos, Esther
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Sanchez-Ospina, Didier
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Ruiz-Priego, Alberto
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Egido, Jesus
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Ortiz Arduán, Alberto
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González-Parra, Emilio
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