Regulatory lymphoid and myeloid cells determine the cardiac immunopathogenesis of Trypanosoma cruzi infection

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dc.contributor.author Fresno, Manuel
dc.contributor.author Gironès, Núria
dc.contributor.other UAM. Departamento de Biología Molecular es_ES
dc.contributor.other Centro de Biología Molecular Severo Ochoa (CBMSO) es_ES
dc.contributor.other Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP) es_ES
dc.date.accessioned 2018-05-24T10:57:58Z
dc.date.available 2018-05-24T10:57:58Z
dc.date.issued 2018-03-01
dc.identifier.citation Frontiers in Microbiology 9.March (2018): Article 351 en_US
dc.identifier.issn 1664-302X es_ES
dc.identifier.uri http://hdl.handle.net/10486/682508
dc.description.abstract Chagas disease is a multisystemic disorder caused by the protozoan parasite Trypanosoma cruzi, which affects ~8 million people in Latin America, killing 7,000 people annually. Chagas disease is one of the main causes of death in the endemic area and the leading cause of infectious myocarditis in the world. T. cruzi infection induces two phases, acute and chronic, where the infection is initially asymptomatic and the majority of patients will remain clinically indeterminate for life. However, over a period of 10-30 years, ~30% of infected individuals will develop irreversible, potentially fatal cardiac syndromes (chronic chagasic cardiomyopathy [CCC]), and/or dilatation of the gastro-int estinal tract (megacolon or megaesophagus). Myocarditis is the most serious and frequent manifestation of chronic Chagas heart disease and appears in about 30% of infected individuals several years after infection occurs. Myocarditis is characterized by a mononuclear cell infiltrate that includes different types of myeloid and lymphoid cells and it can occur also in the acute phase. T. cruzi infects and replicates in macrophages and cardiomyocytes as well as in other nucleated cells. The pathogenesis of the chronic phase is thought to be dependent on an immune-inflammatory reaction to a low-grade replicative infection. It is known that cytokines produced by type 1 helper CD4+ T cells are able to control infection. However, the role that infiltrating lymphoid and myeloid cells may play in experimental and natural Chagas disease pathogenesis has not been completely elucidated, and several reports indicate that it depends on the mouse genetic background and parasite strain and/or inoculum. Here, we review the role that T cell CD4+ subsets, myeloid subclasses including myeloid-derived suppressor cells may play in the immunopathogenesis of Chagas disease with special focus on myocarditis, by comparing results obtained with different experimental animal models en_US
dc.description.sponsorship This work was supported by NG grant from Ministerio de Economía y competitividad SAF2015-63868-R (MINECO/FEDER); by MF grants from Ministerio de Economía y competitividad SAF2016-75988-R (MINECO/FEDER), Red de Investigación de Centros de Enfermedades Tropicales (RICET RD12/0018/0004), Comunidad de Madrid (S-2010/BMD-2332) and Fundación Ramón Areces en_US
dc.format.extent 10 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Frontiers Media en_US
dc.relation.ispartof Frontiers in Microbiology en_US
dc.rights © 2018 Fresno and Gironès es_ES
dc.subject.other Chagas disease en_US
dc.subject.other Immunoegulation en_US
dc.subject.other MDSCs en_US
dc.subject.other Myocarditis en_US
dc.subject.other Regulatory T cells en_US
dc.subject.other Th1 cells en_US
dc.subject.other Th17 cells en_US
dc.subject.other Trypanosoma cruzi en_US
dc.title Regulatory lymphoid and myeloid cells determine the cardiac immunopathogenesis of Trypanosoma cruzi infection en_US
dc.type article en
dc.subject.eciencia Biología y Biomedicina / Biología es_ES
dc.relation.publisherversion https://doi.org/10.3389/fmicb.2018.00351 es_ES
dc.identifier.doi 10.3389/fmicb.2018.00351 es_ES
dc.identifier.publicationfirstpage Article 351-1 en_US
dc.identifier.publicationissue March en_US
dc.identifier.publicationlastpage Article 351-10 en_US
dc.identifier.publicationvolume 9 es_ES
dc.relation.projectID Gobierno de España. SAF2015-63868-R es_ES
dc.relation.projectID Gobierno de España. RD12/0018/0004 es_ES
dc.relation.projectID Comunidad de Madrid. S-2010/BMD-2332/INDISNET es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Girones Pujol, Nuria (261139)


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