Prospective association between added sugars and frailty in older adults
Entity
UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)Publisher
Oxford University Press; American Society for NutritionDate
2018-04-08Citation
10.1093/ajcn/nqy028
The American Journal of Clinical Nutrition 107.5 (2018): 772-779
ISSN
0002-9165 (print); 1938-3207 (online)DOI
10.1093/ajcn/nqy028Funded by
Dr. Laclaustra’s research activity is funded by Agencia Aragonesa para la Investigación y el Desarrollo (ARAID). This work was supported by CIBERESP and by FIS grants 16/609, 16/1512, 14/00009, and 13/0288 (Instituto de Salud Carlos III, State Secretary of R+D+I, and co-funded by European Regional Development Fund/European Social Fund "Investing in your future"), the FRAILOMIC Initiative (FP7-HEALTH-2012-Proposal no. 305483-2), the 24 ATHLOS project (EU H2020- Project ID: 635316) and the JPI HDHL (SALAMANDER project).Project
Gobierno de España. FIS 16/609; Gobierno de España. FIS 16/1512; Gobierno de España. FIS 16/00009; Gobierno de España. FIS 13/0288; info:eu-repo/grantAgreement/EC/FP7/305483-2; info:eu-repo/grantAgreement/EC/H2020/635316/EU//ATHLOSEditor's Version
https://doi.org/10.1093/ajcn/nqy028Subjects
Sugar; Obesity; Diabetes; Risk factors; Adults; Frailty; MedicinaNote
This is a pre-copyedited, author-produced version of an article accepted for publication in The American Jopurnal of Clinical Nutrition following peer review. The version of record Martin Laclaustra, Fernando Rodriguez-Artalejo, Pilar Guallar-Castillon, Jose R Banegas, Auxiliadora Graciani, Esther Garcia-Esquinas, Jose Ordovas, Esther Lopez-Garcia; Prospective association between added sugars and frailty in older adults, The American Journal of Clinical Nutrition, Volume 107, Issue 5, 1 May 2018, Pages 772–779 is avaible online at: https://doi.org/10.1093/ajcn/nqy028Rights
© 2018 American Society for NutritionAbstract
Background Sugar-sweetened beverages and added sugars (monosaccharides and disaccharides) in the diet are associated with obesity, diabetes, and cardiovascular disease, which are all risk factors for decline in physical function among older adults. Objective The aim of this study was to examine the association between added sugars in the diet and incidence of frailty in older people. Design Data were taken from 1973 Spanish adults ≥60 y old from the Seniors-ENRICA cohort. In 2008-2010 (baseline), consumption of added sugars (including those in fruit juices) was obtained using a validated diet history. Study participants were followed up until 2012-2013 to assess frailty based on Fried's criteria. Statistical analyses were performed with logistic regression adjusted for age, sex, education, smoking status, body mass index, energy intake, self-reported comorbidities, Mediterranean Diet Adherence Score (excluding sweetened drinks and pastries), TV watching time, and leisure-Time physical activity. Results Compared with participants consuming <15 g/d added sugars (lowest tertile), those consuming ≥36 g/d (highest tertile) were more likely to develop frailty (OR: 2.27; 95% CI: 1.34, 3.90; P-Trend = 0.003). The frailty components "low physical activity" and "unintentional weight loss" increased dose dependently with added sugars. Association with frailty was strongest for sugars added during food production. Intake of sugars naturally appearing in foods was not associated with frailty. Conclusions The consumption of added sugars in the diet of older people was associated with frailty, mainly when present in processed foods. The frailty components that were most closely associated with added sugars were low level of physical activity and unintentional weight loss. Future research should determine whether there is a causal relation between added sugars and frailty
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Google Scholar:Laclaustra, Martín
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Rodríguez Artalejo, Fernando
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Guallar Castillón, María Pilar
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Banegas Banegas, José Ramón
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Graciani Pérez-Regadera, Auxiliadora
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García García-Esquinas, Esther
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Ordovas, José
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López García, Esther