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Polymorphisms associated with adalimumab and infliximab response in moderate-to-severe plaque psoriasis

Author
Ovejero-Benito, María C.; Prieto-Pérez, Rocío; Llamas-Velasco, Mar; Muñoz-Aceituno, Ester; Reolid, Alejandra; Saiz-Rodríguez, Miriam; Belmonte, Carmen; Román, Manuel; Ochoa, Dolores; Talegón, María; Cabaleiro, Teresa; Daudén, Esteban; Abad Santos, Franciscountranslated
Entity
UAM. Departamento de Farmacología; UAM. Instituto Teófilo Hernando de I+D del Medicamento (ITH); Instituto de Investigación del Hospital de La Princesa (IP)
Publisher
Future Medicine
Date
2017-12-01
Citation
10.2217/pgs-2017-0143
Pharmacogenomics 19.1 (2018): 7-16
 
 
 
ISSN
1462-2416 (print); 1744-8042 (online)
DOI
10.2217/pgs-2017-0143
Editor's Version
https://doi.org/10.2217/pgs-2017-0143
Subjects
Adalimumab; Anti-TNF drugs; Infliximab; Pharmacogenetics; Psoriasis; Farmacia
URI
http://hdl.handle.net/10486/684692
Rights
© 2018 Future Medicine Ltd.

Abstract

Aims. This study evaluated the influence of pharmacogenetics in psoriatic patients treated with adalimumab and/or infliximab. Materials & methods: Prospective observational study evaluating the association of 124 polymorphisms with the response to adalimumab or infliximab (PASI75) in patients with moderate-to-severe plaque psoriasis at 3 months (n = 95) and 6 months of treatment (n = 90). Significant SNPs for univariate analysis were subjected to multivariate analysis. Results: Five SNPs were associated with PASI75 at 3 months: rs6661932 (IVL), rs2546890 (IL-12B), rs2145623 (NFKBIA), rs9304742 (ZNF816A) and rs645544 (SLC9A8). Furthermore, rs1061624 (TNFR1B) was associated with PASI75 at 6 months. Conclusion: Nevertheless, these biomarkers should be validated in large-scale studies before implementation in clinical practice.
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Google™ Scholar:Ovejero-Benito, María C. - Prieto-Pérez, Rocío - Llamas-Velasco, Mar - Muñoz-Aceituno, Ester - Reolid, Alejandra - Saiz-Rodríguez, Miriam - Belmonte, Carmen - Román, Manuel - Ochoa, Dolores - Talegón, María - Cabaleiro, Teresa - Daudén, Esteban - Abad Santos, Francisco

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  • Producción científica en acceso abierto de la UAM [14730]

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Universidad Autónoma de Madrid. Biblioteca
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