Plasma retinol levels and high-sensitivity C-reactive protein in prepubertal children
EntityUAM. Departamento de Pediatría
PublisherMDPI (Basel, Switzerland)
10.3390/nu10091257Nutrients 10.9 (2018): 1257
Funded byThis research was funded by grants from the “Fondo de Investigación Sanitaria” (FIS 11/00344 and FIS 14/00344), Biobank grant FEDER RD09/0076/00101 and SAF2015-70747-R from the “Ministerio de Economía y Competitividad e Innovación”. Olaya de Dios is a fellow of the Conchita Rábago Foundation. Leticia Herrero is the recipient of a research contract from the Board of Education , Youth, and Sport of the Madrid regional government, the European Social Fund, and the Youth Employment Initiative
ProjectGobierno de España. FIS 11/00344; Gobierno de España. FIS 14/00344; Gobierno de España. RD09/0076/00101; Gobierno de España. SAF2015-70747-R
SubjectsC-reactive protein; Hs-CRP concentrations; Fat-soluble plasma antioxidants; Plasma retinol concentrations; Prepubertal children; Medicina
Rights© 2018 By the Authors. Licensee MDPI, Basel, Switzerland
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
The relationship between C-reactive protein (CRP) levels and plasma antioxidants has been established in adults. However, the association has been rarely investigated in healthy children. Thus, we examined the cross-sectional association of high-sensitivity CRP (hs-CRP) levels with fat-soluble plasma antioxidant concentrations in a cohort of healthy prepubertal children. We determined hs-CRP levels in 543 healthy six–eight-year-old children using a high-sensitivity CRP enzyme-linked immuno sorbent assay (ELISA) kit. The plasma concentrations of lipids, apolipoproteins and lipid-soluble antioxidants (α-tocopherol, γ-tocopherol, lycopene, α-carotene, β-carotene and retinol) were determined using standardized methods. Pearson correlation analysis showed significant correlations between plasma hs-CRP and α-carotene and retinol concentrations. After adjusting by sex, body mass index (BMI) and lipid levels, only the association with retinol remains significant, with children in the highest hs-CRP tertile group (hs-CRP ≥ 0.60 mg/dL) showing significantly lower levels of retinol than those from the tertiles 1 and 2. A stepwise linear regression selected retinol, BMI, apo A-I and sex as predictors of hs-CRP levels, in a model explaining 19.2% of the variability of hs-CRP. In conclusion, in healthy prepubertal children, after adjusting by sex, BMI and lipid levels, hs-CRP concentrations were highly associated with plasma retinol, which is transported in blood bound to retinol-binding protein but were not associated with the lipoprotein-bound antioxidants
Google Scholar:Dios, Olaya de - Navarro, Pilar - Ortega-Senovilla, Henar - Herrero, Leticia - Gavela Pérez, Teresa - Soriano Guillén, Leandro - Lasunción, Miguel A. - Garcés, Carmen
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