The human gut pan-microbiome presents a compositional core formed by discrete phylogenetic units
Entity
UAM. Departamento de BiologíaPublisher
Nature Research (part of Springer Nature)Date
2018-09-19Citation
10.1038/s41598-018-32221-8
Scientific Reports 8 (2018): 14069
ISSN
2045-2322)DOI
10.1038/s41598-018-32221-8Funded by
This work was funded by the Spanish Ministry of Economy grant BIO2016-80101-R awarded to DACProject
Gobierno de España. BIO2016-80101-REditor's Version
https://doi.org/10.1038/s41598-018-32221-8Subjects
Human; Complex community of microbes; Microbiome datasets; 16S rRNA gene; Phylogenetic depth; Biología y Biomedicina / BiologíaRights
© The Author(s) 2018Abstract
The complex community of microbes living in the human gut plays an important role in host wellbeing.
However, defining a ‘healthy’ gut microbiome in terms of composition has remained an elusive task,
despite its anticipated medical and scientific importance. In this regard, a central question has been
if there is a ‘core’ microbiome consisting of bacterial groups common to all healthy humans. Recent
studies have been able to define a compositional core in human gut microbiome datasets in terms
of taxonomic assignments. However, the description of the core microbiome in terms of taxonomic
assignments may not be adequate when considering subsequent analyses and applications. Through
the implementation of a dynamic clustering approach in the meta-analyisis of comprehensive 16S rRNA
marker gene datasets, this study found that the human gut pan-microbiome presents a preeminent
compositional core comprised of discrete units of varying phylogenetic depth present in all individuals
studied. Since both microbial traits and ecological coherence show signs of phylogenetic conservation,
this outcome provides a new conceptual framework in the study of the ecosystem, as well as important
practical considerations which should be taken into account in future research
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Google Scholar:Aguirre de Cárcer García, Daniel
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