Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts
Entity
UAM. Departamento de Química Física Aplicada; Instituto de Investigación en Ciencias de la Alimentación (CIAL)Publisher
BMC (part of Springer Nature)Date
2018-09-17Citation
10.1186/s12906-018-2322-6
BMC Complementary and Alternative Medicine 18.1 (2018): 254
ISSN
1472-6882DOI
10.1186/s12906-018-2322-6Funded by
This work has been supported by Ministerio de Economía y Competitividad del Gobierno de España (MINECO, Plan Nacional I + D + i) AGL2016–76736-C3/FEDER, and Gobierno Regional de la Comunidad de Madrid (P2013/ABI-2728, ALIBIRD-CM)Project
Gobierno de España. AGL2016–76736-C3/FEDER; Comunidad de Madrid. P2013/ABI-2728/ALIBIRD-CMEditor's Version
https://doi.org/10.1186/s12906-018-2322-6Subjects
Pancreatic cancer; Asteraceae; Lamiaceae; Chemotherapeutic agents; 5-Fluororacil; Física; QuímicaRights
© The Author(s). 2018Abstract
Background: Pancreatic cancer is one of the most aggressive and mortal cancers. Although several drugs have been
proposed for its treatment, it remains resistant and new alternatives are needed. In this context, plants and their
derivatives constitute a relevant source of bioactive components which might efficiently inhibit tumor cell progression.
Methods: In this study, we have analyzed the potential anti-carcinogenic effect of different Asteraceae (Achillea millefolium
and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) plant extracts obtained by different
green technologies (Supercritical CO2 Extraction –SFE- and Ultrasonic Assisted Extraction –UAE-) to identify efficient plant
extracts against human pancreatic cancer cells that could constitute the basis of novel treatment approaches.
Results: Asteraceae extracts showed better results as antitumoral agents than Lamiaceae by inducing cytotoxicity and
inhibiting cell transformation, and SFE extracts were most efficient than UAE extracts. In addition, SFE derived plant extracts
from Achillea millefolium and Calendula officinalis displayed synergism with the chemotherapeutic 5-Fluororacil.
Conclusion: These results show how Yarrow and Marigold SFE-derived extracts can inhibit pancreatic cancer cell growth,
and could be proposed for a comprehensive study to determine the molecular mechanisms involved in their bioactivity
with the final aim to propose them as potential adjuvants in pancreatic cancer therapy
Files in this item

Google Scholar:Mouhid, Lamia
-
Gómez de Cedrón, Marta
-
Vargas, Teodoro
-
García-Carrascosa, Elena
-
Herranz, Nieves
-
García-Risco, Mónica
-
Reglero Rada, Guillermo
-
Fornari, Tiziana
-
Ramírez de Molina, Ana
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Yarrow supercritical extract exerts antitumoral properties by targeting lipid metabolism in pancreatic cancer
Mouhid, Lamia; De Cedrón, Marta Gómez; García-Carrascosa, Elena; Reglero, Guillermo; Fornari, Tiziana; De Molina, Ana Ramírez
2019-03-26 -
Marigold Supercritical Extract as Potential Co-adjuvant in Pancreatic Cancer: The Energetic Catastrophe Induced via BMP8B Ends Up With Autophagy-Induced Cell Death
Gómez de Cedrón, Marta; Mouhid, Lamia; García-Carrascosa, Elena; Fornari, Tiziana; Reglero, Guillermo; Ramírez de Molina, Ana
2020-01-24 -
Expression of MicroRNA-15b and the glycosyltransferase GCNT3 correlates with antitumor efficacy of rosemary diterpenes in colon and pancreatic cancer
González-Vallinas, Margarita; Molina, Susana; Vicente, Gonzalo; Zarza, Virginia; Martín-Hernández, Roberto; García-Risco, Mónica Rodriguez; Fornari, Tiziana; Reglero, Guillermo; De Molina, Ana Ramírez
2014-06-03