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Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts

Author
Mouhid, Lamia; Gómez de Cedrón, Marta; Vargas, Teodoro; García-Carrascosa, Elena; Herranz, Nieves; García-Risco, Mónica; Reglero Rada, Guillermo; Fornari, Tiziana; Ramírez de Molina, Ana
Entity
UAM. Departamento de Química Física Aplicada; Instituto de Investigación en Ciencias de la Alimentación (CIAL)
Publisher
BMC (part of Springer Nature)
Date
2018-09-17
Citation
10.1186/s12906-018-2322-6
BMC Complementary and Alternative Medicine 18.1 (2018): 254
 
 
 
ISSN
1472-6882
DOI
10.1186/s12906-018-2322-6
Funded by
This work has been supported by Ministerio de Economía y Competitividad del Gobierno de España (MINECO, Plan Nacional I + D + i) AGL2016–76736-C3/FEDER, and Gobierno Regional de la Comunidad de Madrid (P2013/ABI-2728, ALIBIRD-CM)
Project
Gobierno de España. AGL2016–76736-C3/FEDER; Comunidad de Madrid. P2013/ABI-2728/ALIBIRD-CM
Editor's Version
https://doi.org/10.1186/s12906-018-2322-6
Subjects
Pancreatic cancer; Asteraceae; Lamiaceae; Chemotherapeutic agents; 5-Fluororacil; Física; Química
URI
http://hdl.handle.net/10486/685845
Rights
© The Author(s). 2018

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

Background: Pancreatic cancer is one of the most aggressive and mortal cancers. Although several drugs have been proposed for its treatment, it remains resistant and new alternatives are needed. In this context, plants and their derivatives constitute a relevant source of bioactive components which might efficiently inhibit tumor cell progression. Methods: In this study, we have analyzed the potential anti-carcinogenic effect of different Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) plant extracts obtained by different green technologies (Supercritical CO2 Extraction –SFE- and Ultrasonic Assisted Extraction –UAE-) to identify efficient plant extracts against human pancreatic cancer cells that could constitute the basis of novel treatment approaches. Results: Asteraceae extracts showed better results as antitumoral agents than Lamiaceae by inducing cytotoxicity and inhibiting cell transformation, and SFE extracts were most efficient than UAE extracts. In addition, SFE derived plant extracts from Achillea millefolium and Calendula officinalis displayed synergism with the chemotherapeutic 5-Fluororacil. Conclusion: These results show how Yarrow and Marigold SFE-derived extracts can inhibit pancreatic cancer cell growth, and could be proposed for a comprehensive study to determine the molecular mechanisms involved in their bioactivity with the final aim to propose them as potential adjuvants in pancreatic cancer therapy
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Google™ Scholar:Mouhid, Lamia - Gómez de Cedrón, Marta - Vargas, Teodoro - García-Carrascosa, Elena - Herranz, Nieves - García-Risco, Mónica - Reglero Rada, Guillermo - Fornari, Tiziana - Ramírez de Molina, Ana

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  • Producción científica en acceso abierto de la UAM [14696]

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