A miR-155–Peli1–c-Rel pathway controls the generation and function of T follicular helper cells
Entity
UAM. Departamento de BioquímicaPublisher
Rockefeller University PressDate
2018-08-01Citation
10.1084/jem.20160204
Journal of Experimental Medicine 213.9 (2018): 1901-1919
ISSN
0022-1007 (print); 1540-9538 (online)DOI
10.1084/jem.20160204Funded by
C. Xiao is a Pew Scholar in Biomedical Sciences. This study is supported by the PEW Charitable Trusts, Cancer Research Institute, Lupus Research Institute, National Institutes of Health (grants R01AI087634, R01AI089854, R56AI110403, and R56AI121155 to C. Xiao and grants R01AI103646 and R01AI108651 to L.-F. Lu), National Natural Science Foundation of China (grant 31570882 to W.-H. Liu, grant 31570883 to N. Xiao, and grant 31570911 to G. Fu), 1000 Young Talents Program of China (grant K08008 to N. Xiao), the Fundamental Research Funds for the Central Universities of the People’s Republic of China (grant 20720150065 to N. Xiao and G. Fu), the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, Information and Communications Technology, and Future Planning (grant NRF-2015R1C1A1A01052387 to S.G. Kang), and a 2016 research grant from Kangwon National University (to S.G. Kang)Editor's Version
https://doi.org/10.1084/jem.20160204Subjects
MicroRNA (miRNA); Generation of T follicular helper (Tfh) cells; Novel; miR-155-Peli1-c-Rel pathway; MedicinaRights
© 2016 Liu et al.Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional.
Abstract
MicroRNA (miRNA) deficiency impairs the generation of T follicular helper (Tfh) cells, but the contribution of individual miRNAs to this phenotype remains poorly understood. In this study, we performed deep sequencing analysis of miRNAs expressed in Tfh cells and identified a five-miRNA signature. Analyses of mutant mice deficient of these miRNAs revealed that miR-22 and miR-183/96/182 are dispensable, but miR-155 is essential for the generation and function of Tfh cells. miR-155 deficiency led to decreased proliferation specifically at the late stage of Tfh cell differentiation and reduced CD40 ligand (CD40L) expression on antigen-specific CD4+T cells. Mechanistically, miR-155 repressed the expression of Peli1, a ubiquitin ligase that promotes the degradation of the NF-κB family transcription factor c-Rel, which controls cellular proliferation and CD40L expression. Therefore, our study identifies a novel miR-155-Peli1-c-Rel pathway that specifically regulates Tfh cell generation and function
Files in this item
Google Scholar:Liu, Wen‑Hsien
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Kang, Seung Goo
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Huang, Zhe
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Wu, Cheng‑Jang
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Jin, Hyun Yong
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Maine, Christian J.
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Liu, Yi
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Shepherd, Jovan
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Sabouri‑Ghomi, Mohsen
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González‑Martín, Alicia
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Xu, Shunbin
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Hoffmann, Alexander
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Zheng, Ye
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Lu, Lin-Fa
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Xiao, Nengming
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Fu, Guo
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Xiao, Changchun
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