Regulation of B-cell development and tolerance by different members of the miR-17∼1/492 family microRNAs
EntityUAM. Departamento de Bioquímica
PublisherNature Research (part of Springer Nature)
10.1038/ncomms12207Nature Communications 7.1 (2016): 2658
Funded byThis study is supported by the PEW Charitable Trusts, Cancer Research Institute, Lupus Research Institute and National Institute of Health (R01AI087634, R01AI089854, R56AI110403 and R56AI121155 to C.X.)
SubjectsB-cell; Development and tolerance; miR-17B92; microRNAs; Medicina
Rights© The Author(s) 2016
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
The molecular mechanisms that regulate B-cell development and tolerance remain incompletely understood. In this study, we identify a critical role for the miR-17∼1/492 microRNA cluster in regulating B-cell central tolerance and demonstrate that these miRNAs control early B-cell development in a cell-intrinsic manner. While the cluster member miR-19 suppresses the expression of Pten and plays a key role in regulating B-cell tolerance, miR-17 controls early B-cell development through other molecular pathways. These findings demonstrate differential control of two closely linked B-cell developmental stages by different members of a single microRNA cluster through distinct molecular pathways
Google Scholar:Lai, Maoyi - Gonzalez-Martin, Alicia - Cooper, Anthony B. - Oda, Hiroyo - Jin, Hyun Yong - Shepherd, Jovan - He, Linling - Zhu, Jiang - Nemazee, David - Xiao, Changchun
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