Detection of activation sequences in spiking-bursting neurons by means of the recognition of intraburst neural signatures
Entity
UAM. Departamento de Ingeniería InformáticaPublisher
Nature Research (part of Springer Nature)Date
2018-11-13Citation
10.1038/s41598-018-34757-1
Scientific Reports 8.1 (2018): 16726
ISSN
2045-2322DOI
10.1038/s41598-018-34757-1Funded by
R.L. was supported by MINECO/FEDER DPI2015-65833-PProject
Gobierno de España. DPI2015-65833-PEditor's Version
https://doi.org/10.1038/s41598-018-34757-1Subjects
Neural information processing; Patterns of sequential activity; Bursting neurons; Neural signature; Presynaptic activation; InformáticaRights
© 2018, The Author(s)Abstract
Bursting activity is present in many cells of different nervous systems playing important roles in neural information processing. Multiple assemblies of bursting neurons act cooperatively to produce coordinated spatio-temporal patterns of sequential activity. A major goal in neuroscience is unveiling the mechanisms underlying neural information processing based on this sequential dynamics. Experimental findings have revealed the presence of precise cell-type-specific intraburst firing patterns in the activity of some bursting neurons. This characteristic neural signature coexists with the information encoded in other aspects of the spiking-bursting signals, and its functional meaning is still unknown. We investigate the ability of a neuron conductance-based model to detect specific presynaptic activation sequences taking advantage of intraburst fingerprints identifying the source of the signals building up a sequential pattern of activity. Our simulations point out that a reader neuron could use this information to contextualize incoming signals and accordingly compute a characteristic response by relying on precise phase relationships among the activity of different emitters. This would provide individual neurons enhanced capabilities to control and negotiate sequential dynamics. In this regard, we discuss the possible implications of the proposed contextualization mechanism for neural information processing.
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Google Scholar:Carrillo-Medina, José Luis
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Latorre Camino, Roberto
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