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dc.contributor.authorCabrera-Lobera, Natalia
dc.contributor.authorQuirós, M. Teresa
dc.contributor.authorBuñuel Magdalena, María Elena 
dc.contributor.authorCárdenas Morales, Diego Jesús 
dc.contributor.otherUAM. Departamento de Química Orgánicaes_ES
dc.date.accessioned2019-03-20T12:17:19Z
dc.date.available2019-03-20T12:17:19Z
dc.date.issued2019-01-23
dc.identifier.citationCatalysis Science and Technology 9.4 (2019): 1021-1029en_US
dc.identifier.issn2044-4753 (print)es_ES
dc.identifier.issn2044-4761 (online)es_ES
dc.identifier.urihttp://hdl.handle.net/10486/687077
dc.description.abstractWe report a full study on the novel regioselective Ni-catalyzed hydroborylative cyclization of enynes using HBpin as the borylation agent. Alkyl and alkenyl boronates can be obtained depending on the substituent on the alkyne. The reaction takes place under smooth conditions with an inexpensive catalytic Ni-based system, constituting a fully atom-economic eco-friendly method. This process shows a broad scope, allowing the formation of carbo- and heterocycles in moderate to good yields. The utility of the resulting boronates is also illustrated. We have studied the reaction mechanism both experimentally and computationally. The process involves initial oxidative cyclometalation to Ni(0)(xantphos) species followed by the key C-B bond formation through σ-bond metathesis and reductive eliminationen_US
dc.description.sponsorshipWe thank the Spanish MINECO for funding (Grant CTQ2016-79826-R) and a Juan de la Cierva fellowship to M. T. Q., the MECD for a FPU fellowship to N. C.-L., and the Centro de Computación Científica-UAMen_US
dc.format.extent10 pag.en_US
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofCatalysis Science and Technologyen_US
dc.rights© 2019 The Royal Society of Chemistryen_US
dc.subject.otherCyclizationen_US
dc.subject.otherCatalysisen_US
dc.subject.otherRegioselectivityen_US
dc.titleAtom-economical regioselective Ni-catalyzed hydroborylative cyclization of enynes: Development and mechanismen_US
dc.typearticleen
dc.subject.ecienciaQuímicaes_ES
dc.date.embargoend2020-01-23
dc.relation.publisherversionhttp://dx.doi.org/10.1039/c8cy02568aes_ES
dc.identifier.doi10.1039/c8cy02568aes_ES
dc.identifier.publicationfirstpage1021es_ES
dc.identifier.publicationissue4es_ES
dc.identifier.publicationlastpage1021-1029es_ES
dc.identifier.publicationvolume9es_ES
dc.relation.projectIDGobierno de España. CTQ2016-79826-Res_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.rights.accessRightsopenAccessen
dc.authorUAMCardenas Morales, Diego Jesús (259091)
dc.facultadUAMFacultad de Ciencias
dc.institutoUAMInstituto de Investigación Avanzada en Ciencias Químicas (IAdChem)


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