A General Asymmetric Formal Synthesis of Aza-Baylis–Hillman Type Products under Bifunctional Catalysis
Entity
UAM. Departamento de Química OrgánicaPublisher
Wiley-VCH VerlagDate
2018-03-02Citation
10.1002/chem.201705218
Chemistry A European Journal 24.13 (2018): 3117-3121
ISSN
0947-6539 (print); 1521-3765 (online)DOI
10.1002/chem.201705218Funded by
Financial support from the Spanish Government (CTQ2015-64561-R), the European Research Council (ERC-CG, contract number: 647550), is also gratefully acknowledgedProject
Gobierno de España. CTQ2015-64561-R; info:eu-repo/grantAgreement/EC/FP7/647550Editor's Version
https://doi.org/10.1002/chem.201705218Subjects
Baylis–Hillman reaction; Asymmetric synthesis; Bifunctional catalysis; Silyl-enol ethers; Thiourea; QuímicaNote
This is the peer reviewed version of the following article: Chemistry A European Journal 24.13 (2018): 3117-3121, which has been published in final form at https://doi.org/10.1002/chem.201705218. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsRights
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimAbstract
Weinheim A new organocatalytic strategy for the synthesis of enantioenriched aza-Baylis–Hillman type products via a frustrated vinylogous reaction is presented. This process proceeds under mild conditions with good yields, completed Z/E selectivity and excellent enantioselectivities. Moreover, easy derivatizations of the final products led to important building blocks of organic synthesis such as 1,3-aminoalcohols and Lewis base catalysts
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Google Scholar:Frías, María
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Carrasco, Ana Cristina
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Fraile Carrasco, Alberto
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Alemán Lara, José Julián
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