Show simple item record

dc.contributor.authorSuárez-Cabrera, Cristian
dc.contributor.authorPeña, Bárbara de la
dc.contributor.authorGonzález, Laura L.
dc.contributor.authorPage, Angustias
dc.contributor.authorMartínez-Fernández, Mónica
dc.contributor.authorCasanova, M. Llanos
dc.contributor.authorParamio, Jesús M.
dc.contributor.authorRojo-Sebastián, Alejandro
dc.contributor.authorMoreno Bueno, Gema 
dc.contributor.authorMaroto, Alicia
dc.contributor.authorRamírez, Ángel
dc.contributor.authorNavarro, Manuel
dc.contributor.otherUAM. Departamento de Bioquímicaes_ES
dc.contributor.otherInstituto de Investigaciones Biomédicas "Alberto Sols" (IIBM)es_ES
dc.contributor.otherInstituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)es_ES
dc.date.accessioned2019-06-12T13:58:15Z
dc.date.available2019-06-12T13:58:15Z
dc.date.issued2018-08-29
dc.identifier.citationScientific Reports 8 (2018): 13038en_US
dc.identifier.issn2045-2322es_ES
dc.identifier.urihttp://hdl.handle.net/10486/687825
dc.description.abstractAlthough Ras genes are frequently mutated in human tumors, these mutations are uncommon in breast cancer. However, many breast tumors show evidences of Ras pathway activation. In this manuscript, we have analyzed and characterized mouse mammary tumors generated by random Sleeping Beauty transposon mutagenesis and identify ERAS -a member of the RAS family silenced in adult tissues- as a new gene involved in progression and malignancy of breast cancer. Forced expression of ERAS in human non-transformed mammary gland cells induces a process of epithelial-to-mesenchymal transition and an increase in stem cells markers; these changes are mediated by miR-200c downregulation. ERAS expression in human tumorigenic mammary cells leads to the generation of larger and less differentiated tumors in xenotransplant experiments. Immunohistochemical, RT-qPCR and bioinformatics analysis of human samples show that ERAS is aberrantly expressed in 8–10% of breast tumors and this expression is associated with distant metastasis and reduced metastasis-free survival. In summary, our results reveal that inappropriate activation of ERAS may be important in the development of a subset of breast tumors. These findings open the possibility of new specific treatments for this subset of ERAS-expressing tumors.en_US
dc.description.sponsorshipThis research was supported partially by funds from Fondo Europeo de Desarrollo Regional (FEDER) and by grants from the Spanish Government PI16/00161, PI16/00134, PIE15/00076, PI17/00578, CB/16/00228, CB16/12/00295 and RD12/0036/0009 from Instituto de Salud Carlos III (Ministerio de Economía y Competitividad) and SAF-2015-66015-R from the Ministerio de Economía y Competitividad. Biobanco 1 + 12 is supported by Instituto de Salud Carlos IIIen_US
dc.format.extent17 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherNature Research (part of Springer Nature)en_US
dc.relation.ispartofScientific Reportsen_US
dc.rights© 2018, The Author(s)en_US
dc.subject.otherRas geneen_US
dc.subject.otherHuman tumorsen_US
dc.subject.otherBreast canceren_US
dc.subject.otherMetastasisen_US
dc.subject.otherNew specific treatmentsen_US
dc.titleThe Ras-related gene ERAS is involved in human and murine breast canceren_US
dc.typearticleen
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-018-31326-4es_ES
dc.identifier.doi10.1038/s41598-018-31326-4es_ES
dc.identifier.publicationfirstpage13038-1es_ES
dc.identifier.publicationissue8es_ES
dc.identifier.publicationlastpage13038-17es_ES
dc.relation.projectIDGobierno de España. PI16/00161es_ES
dc.relation.projectIDGobierno de España. PI16/00134es_ES
dc.relation.projectIDGobierno de España. PIE15/00076es_ES
dc.relation.projectIDGobierno de España. PI17/00578es_ES
dc.relation.projectIDGobierno de España. CB/16/00228es_ES
dc.relation.projectIDGobierno de España. CB16/12/00295es_ES
dc.relation.projectIDGobierno de España. RD12/0036/0009es_ES
dc.relation.projectIDGobierno de España. SAF-2015-66015-Res_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimientoes_ES
dc.rights.accessRightsopenAccessen
dc.facultadUAMFacultad de Medicina
dc.institutoUAMInstituto de Investigaciones Biomédicas "Alberto Sols" (IIBM)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record