Frontotemporal dementia-associated N279K tau mutation localizes at the nuclear compartment
Entity
UAM. Departamento de Anatomía, Histología y Neurociencia; Centro de Biología Molecular Severo Ochoa (CBM)Publisher
Frontiers MediaDate
2018-07-12Citation
10.3389/fncel.2018.00202
Frontiers in Cellular Neuroscience 12 (2018): 202
ISSN
1662-5102DOI
10.3389/fncel.2018.00202Funded by
This study was funded by grants from the Spanish Ministry of Economy and Competitiveness (Ministerio de Economía y Competitividad; SAF-2014-53040-P (JA) and BFU2016-77885- P (FH)), the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, ISCIII; JA).Project
Gobierno de España. SAF-2014-53040-P; Gobierno de España. BFU2016-77885- PEditor's Version
https://doi.org/10.3389/fncel.2018.00202Subjects
Alzheimer; FTDP-17; Nucleus; Tau; Transport; MedicinaRights
© 2018 Ritter, Avila, García-Escudero, Hernández and PérezAbstract
Tau is a microtubule-associated protein that plays an important role in Alzheimer’s disease and related tauopathies. Approximately one-half of all cases of Frontotemporal dementia with parkinsonism-17 (FTDP-17) are caused by mutations in the MAPT gene. The N279K mutation is one of the three mutations more prevalent in FTDP-17 cases. Several studies have demonstrated that N279K Tau mutation alters alternative splicing inducing the presence of exon 10. Tau is mainly found in the cytosol of neuronal cells although it has also been localized within the nucleus. Here we demonstrate by biochemical and immunohistochemistry studies in COS-7 cells, that the proportion of mutant N279K Tau increases compared with wild-type at the cell nucleus although cell viability is not affected. These data will provide us with a better outline of the nuclear role of tau protein offering new clues related with this tauopathie.
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Google Scholar:Ritter, Maxi L.
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Avila, Jesús
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García-Escudero Barreras, María Vega
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Hernández Pérez, Félix
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Pérez Martínez, María Mar
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