Beneficial effects of murtilla extract and madecassic acid on insulin sensitivity and endothelial function in a model of diet-induced obesity
PublisherNature Research (part of Springer Nature)
10.1038/s41598-018-36555-1Scientific Reports 9.1 (2019): 599
Funded byThis study was supported by BFU2011-25303, GR921645-Santander, Fundación Mutua Madrileña, Fundación Eugenio Rodríguez Pascual, SESCAMET, project FONDECYT1130155, grant CONICYT de Doctorado Nacional, grant CONICYT de Apoyo de Tesis 21130672, and grant CONICYT de Pasantía Doctoral
ProjectGobierno de España. BFU2011-25303
SubjectsMurtilla; Extrac; Beneficial effect; Insulin; Endothelial function; Obesity; Medicina
Rights© 2019, The Author(s)
Infusions of murtilla leaves exhibit antioxidant, analgesic, and anti-inflammatory properties. Several compounds that are structurally similar to madecassic acid (MA), a component of murtilla leaf extract (ethyl acetate extract, EAE), have been shown to inhibit protein tyrosine phosphatase 1B (PTP1P). The aim of this study was to evaluate if EAE and two compounds identified in EAE (MA and myricetin [MYR]) could have a beneficial effect on systemic and vascular insulin sensitivity and endothelial function in a model of diet-induced obesity. Experiments were performed in 5-week-old male C57BL6J mice fed with a standard (LF) or a very high-fat diet (HF) for 4 weeks and treated with EAE, MA, MYR, or the vehicle as control (C). EAE significantly inhibited PTP1B. EAE and MA, but not MYR, significantly improved systemic insulin sensitivity in HF mice and vascular relaxation to Ach in aorta segments, due to a significant increase of eNOS phosphorylation and enhanced nitric oxide availability. EAE, MA, and MYR also accounted for increased relaxant responses to insulin in HF mice, thus evidencing that the treatments significantly improved aortic insulin sensitivity. This study shows for the first time that EAE and MA could constitute interesting candidates for treating insulin resistance and endothelial dysfunction associated with obesity.
Google Scholar:Arancibia-Radich, Jorge - González-Blázquez, Raquel - Alcalá, Martín - Martín-Ramos, Miriam - Viana, Marta - Arribas Rodríguez, Silvia Magdalena - Delporte, Carla - Fernández-Alfonso, María S. - Somoza, Beatriz - Gil-Ortega, Marta
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