UAM_Biblioteca | Unified search engine | Scientific Production Portal | UAM Research Data Repository
Universidad Autónoma de Madrid
Biblos-e Archivo
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram
    • español
    • English
  • English 
    • español
    • English
  • Log in
JavaScript is disabled for your browser. Some features of this site may not work without it.

Search Biblos-e Archivo

Advanced Search

Browse

All of Biblos-e ArchivoCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultiesThis CollectionBy Issue DateAuthorsTitlesSubjectsFaculties

My Account

Log inRegister

Statistics

View Usage Statistics

Help

Information about Biblos-e ArchivoI want to submit my workI want to submit my doctoral thesisFrequently Asked QuestionsCopyrightsFinancial Agencies and OA policy

UAM_Biblioteca

View Item 
  •   Biblos-e Archivo
  • 1 - Producción científica en acceso abierto de la UAM
  • Producción científica en acceso abierto de la UAM
  • View Item
  •   Biblos-e Archivo
  • 1 - Producción científica en acceso abierto de la UAM
  • Producción científica en acceso abierto de la UAM
  • View Item

Access to Benzazepinones by Pd-Catalyzed Remote C-H Carbonylation of γ-Arylpropylamine Derivatives

Author
Martínez-Mingo, Mario; Rodríguez, Nuria; Gómez Arrayás, Ramón; Carretero, Juan C.
Entity
UAM. Departamento de Química Orgánica
Publisher
American Chemical Society
Date
2019-06-07
Citation
10.1021/acs.orglett.9b01523
Organic Letters 21.11 (2019): 4345-4349
 
 
 
ISSN
1523-7052 (online); 1523-7060 (print)
DOI
10.1021/acs.orglett.9b01523
Funded by
We thank the Spanish Ministerio de Economía y Competitividad (Project CTQ2015-66954-P, MINECO/FEDER, UE) for financial support. M.M.-M. thanks MINECO for a FPI predoctoral fellow-ship. N.R. thanks the European Commission for a Marie Curie Ca-reer Integration Grant (CIG: CHAAS-304085). Prof. Inés Alonso (Departamento de Química Orgánica, UAM) is gratefully acknowl-edged for helpful discussions
Project
Gobierno de España. CTQ2015-66954-P; info:eu-repo/grantAgreement/EC/FP7/304085
Editor's Version
https://doi.org/10.1021/acs.orglett.9b01523
Subjects
Activation analysis; Catalysis; Bond functionalization; Química
URI
http://hdl.handle.net/10486/688514
Note
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/abs/10.1021/acs.orglett.9b01523. The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.orglett.9b01523. Experimental procedures and spectral data for all new compounds (PDF): https://pubs.acs.org/doi/suppl/10.1021/acs.orglett.9b01523/suppl_file/ol9b01523_si_001.pdf
Rights
© 2019 American Chemical Society

Abstract

A general method for the construction of seven-membered rings through Pd-catalyzed C(sp2)-H carbonylation at the remote ϵ-position of γ-arylpropylamine derivatives, including chiral α-amino acids, has been developed using Mo(CO)6 as the CO source, furnishing richly functionalized benzo[c]azepin-1-one derivatives. The readily removable N-SO2Py protecting/directing group provides high levels of chemo-, regio- and diastereoselectivity. Furthermore, this method is amenable to the postsynthetic modification of complex molecules such as small peptides
Show full item record

Files in this item

Thumbnail
Name
access_carretero_ol_2019_ps.pdf
Size
674.1Kb
Format
PDF
Thumbnail
Name
SI_access_carretero_ol_2019_ps.pdf
Size
19.12Mb
Format
PDF
Description
Article supporting information

Refworks Export

Delicious Save this on Delicious

Google™ Scholar:Martínez-Mingo, Mario - Rodríguez, Nuria - Gómez Arrayás, Ramón - Carretero, Juan C.

This item appears in the following Collection(s)

  • Producción científica en acceso abierto de la UAM [14696]

Related items

Showing items related by title, author, creator and subject.

  • Overcoming the Necessity of γ-Substitution in δ-C(sp3)–H Arylation: Pd-Catalyzed Derivatization of α-Amino Acids 

    Martínez-Mingo, Mario; García-Viada, Andrés; Alonso, Inés; Rodríguez, Nuria; Gómez Arrayás, Ramón; Carretero Gonzálvez, Juan CarlosAutoridad UAM
    2021-04-19
  • Cobalt-Catalyzed ortho-C−H functionalization/alkyne annulation of benzylamine derivatives: Access to dihydroisoquinolines 

    Martínez, Ángel Manu; Rodríguez, Nuria; Gómez-Arrayás, Ramón; Carretero, Juan C.
    2017-01-01
  • Palladium-Catalyzed Remote ortho-C-H Alkenylation of Alkyl Aryl Sulfones: Access to Densely Functionalized Indane Derivatives 

    Legarda, Pablo D.; García-Rubia, Alfonso; Gómez-Arrayás, Ramón; Carretero, Juan C.
    2016-03-31
All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
Contact Us | Send Feedback
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram
 

 

All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
Contact Us | Send Feedback
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram