Access to Benzazepinones by Pd-Catalyzed Remote C-H Carbonylation of γ-Arylpropylamine Derivatives

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Show simple item record Martínez-Mingo, Mario Rodríguez, Nuria Gómez Arrayás, Ramón Carretero, Juan C.
dc.contributor.other UAM. Departamento de Química Orgánica es_ES 2019-09-09T08:56:00Z 2019-09-09T08:56:00Z 2019-06-07
dc.identifier.citation Organic Letters 21.11 (2019): 4345-4349 es_ES
dc.identifier.issn 1523-7052 (online) es_ES
dc.identifier.issn 1523-7060 (print) es_ES
dc.description This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.orglett.9b01523. Experimental procedures and spectral data for all new compounds (PDF): es_ES
dc.description.abstract A general method for the construction of seven-membered rings through Pd-catalyzed C(sp2)-H carbonylation at the remote ϵ-position of γ-arylpropylamine derivatives, including chiral α-amino acids, has been developed using Mo(CO)6 as the CO source, furnishing richly functionalized benzo[c]azepin-1-one derivatives. The readily removable N-SO2Py protecting/directing group provides high levels of chemo-, regio- and diastereoselectivity. Furthermore, this method is amenable to the postsynthetic modification of complex molecules such as small peptides es_ES
dc.description.sponsorship We thank the Spanish Ministerio de Economía y Competitividad (Project CTQ2015-66954-P, MINECO/FEDER, UE) for financial support. M.M.-M. thanks MINECO for a FPI predoctoral fellow-ship. N.R. thanks the European Commission for a Marie Curie Ca-reer Integration Grant (CIG: CHAAS-304085). Prof. Inés Alonso (Departamento de Química Orgánica, UAM) is gratefully acknowl-edged for helpful discussions es_ES
dc.format.extent 5 pag. es_ES
dc.format.mimetype application/pdf es_ES
dc.language.iso eng es_ES
dc.publisher American Chemical Society es_ES
dc.relation.ispartof Organic Letters es_ES
dc.rights © 2019 American Chemical Society es_ES
dc.subject.other Activation analysis es_ES
dc.subject.other Catalysis es_ES
dc.subject.other Bond functionalization es_ES
dc.title Access to Benzazepinones by Pd-Catalyzed Remote C-H Carbonylation of γ-Arylpropylamine Derivatives es_ES
dc.type article es_ES
dc.subject.eciencia Química es_ES 2020-06-07
dc.relation.publisherversion es_ES
dc.identifier.doi 10.1021/acs.orglett.9b01523 es_ES
dc.identifier.publicationfirstpage 4345 es_ES
dc.identifier.publicationissue 11 es_ES
dc.identifier.publicationlastpage 4349 es_ES
dc.identifier.publicationvolume 21 es_ES
dc.relation.projectID Gobierno de España. CTQ2015-66954-P es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/304085 es_ES
dc.type.version info:eu-repo/semantics/acceptedVersion es_ES
dc.rights.accessRights openAccess es_ES
dc.authorUAM Martínez Mingo, Mario (279590)
dc.authorUAM Gómez Arrayas, Ramón Jesús (260197)
dc.authorUAM Carretero Gonzálvez, Juan Carlos (260121)

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