HCV-coinfection is related to an increased HIV-1 reservoir size in cART-treated HIV patients: a cross-sectional study
Author
López-Huertas, Maria Rosa; Palladino, Claudia; Garrido-Arquero, Marta; Esteban-Cartelle, Beatriz; Sánchez-Carrillo, Marta; Martínez-Román, Paula; Martín-Carbonero, Luz; Ryan, Pablo; Domínguez-Domínguez, Lourdes; Santos Gil, Ignacio de los
Entity
UAM. Departamento de Medicina; Instituto de Investigación del Hospital de La Princesa (IP); Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Publisher
Nature Research (part of Springer Nature)Date
2019-04-03Citation
10.1038/s41598-019-41788-9
Scientific Reports 9 (2019): 5606
ISSN
2045-2322DOI
10.1038/s41598-019-41788-9Funded by
Financial support was provided by the Instituto de Salud Carlos III to VB (PI15CIII/00031), by the Spanish Ministry of Economy and Competitiveness to MC (SAF2016–78480-R) and The SPANISH AIDS Research Network RD16CIII/0002/0001, RD16CIII/0002/0002 and RD16/0025/0013 - ISCIII – FEDER. MRLP is supported by ISCIII - Subdirección General de Evaluacion and European Funding for Regional Development (FEDER) (PIE 13/00040 and RD12/0017/0017 RETIC de SIDA). C.P. is supported by the Portuguese Fundação para a Ciência e Tecnologia (FCT) (grant number SFRH/ BPD/77448/2011 is part of the EDCTP2 programme supported by the European Union). V.B., A.F.R. and N.R. are supported by the Miguel Servet programme from Fondo de Investigación Sanitaria (ISCIII) (grant number CP13/00098, CP14/CIII/00010 and CP14/00198, respectively).Project
Gobierno de España. RD16CIII/0002/0001; Gobierno de España. RD16CIII/0002/0002; Gobierno de España. RD16/0025/0013; Gobierno de España. PIE 13/00040; Gobierno de España. RD12/0017/0017Editor's Version
https://doi.org/10.1038/s41598-019-41788-9Subjects
HIV-1/HCV; T-lymphocyte immune; Patients; Treatment; Elimination of HIV-1; MedicinaRights
© 2019, The Author(s).Abstract
In HIV-1/HCV-coinfected patients, chronic HCV infection leads to an increased T-lymphocyte immune activation compared to HIV-monoinfected patients, thereby likely contributing to increase HIV-1 reservoir that is the major barrier for its eradication. Our objective was to evaluate the influence of HCV coinfection in HIV-1 viral reservoir size in resting (r) CD4+ T-cells (CD25-CD69-HLADR-). Multicenter cross-sectional study of 97 cART-treated HIV-1 patients, including 36 patients with HIV and HCV-chronic co-infection without anti-HCV treatment, 32 HIV patients with HCV spontaneous clearance and 29 HIV-monoinfected patients. rCD4+ T-cells were isolated and total DNA was extracted. HIV viral reservoir was measured by Alu-LTR qPCR. Differences between groups were calculated with a generalized linear model. Overall, 63.9% were men, median age of 41 years and Caucasian. Median CD4+ and CD8+ T-lymphocytes were 725 and 858 cells/mm 3 , respectively. CD4+ T nadir cells was 305 cells/mm 3 . Proviral HIV-1 DNA size was significantly increased in chronic HIV/HCV-coinfected compared to HIV-monoinfected patients (206.21 ± 47.38 vs. 87.34 ± 22.46, respectively; P = 0.009), as well as in spontaneously clarified HCV co-infected patients when compared to HIV-monoinfected individuals (136.20 ± 33.20; P = 0.009). HIV-1/HCV co-infected patients showed a larger HIV-1 reservoir size in comparison to HIV-monoinfected individuals. This increase could lead to a greater complexity in the elimination of HIV-1 reservoir in HIV-1/HCV-coinfected individuals, which should be considered in the current strategies for the elimination of HIV-1 reservoir.
Files in this item
Google Scholar:López-Huertas, Maria Rosa
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Palladino, Claudia
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Garrido-Arquero, Marta
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Esteban-Cartelle, Beatriz
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Sánchez-Carrillo, Marta
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Martínez-Román, Paula
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Martín-Carbonero, Luz
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Ryan, Pablo
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Domínguez-Domínguez, Lourdes
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Santos Gil, Ignacio de los
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De La Fuente Moral, Sara
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Benito, José Miguel
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Rallón, Norma
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Alcamí, José
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Resino, Salvador
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Fernández-Rodríguez, Amanda
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Coiras, Mayte
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Briz, Verónica
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Ángel-Moreno, Alfonso
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Bermejo-Plaza, Laura
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Bisbal, Otilia
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Brochado-Kith, Oscar
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Castro-Álvarez, Juan Miguel
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Cuevas, Guillermo
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Diez-Viñas, Victorino
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Gálvez-Charro, Marta
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García-Fraile, Lucio
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Gómez-Sanz, Alicia
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Lagarde, María
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Matarranz, Mariano
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Mate-Cano, Irene
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Mayoral-Muñoz, Mario
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Muñoz-Muñoz, María
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Pulido, Federico
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Rubio, Rafael
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Santacreu, Mireia
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Sanz-Sanz, Jesús
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Taveira, Nuno
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Troya, Jesús
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Cortegano, Isabel
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Gaspar, María Luisa
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