The dual-specificity phosphatase 10 (DUSP10): Its role in cancer, inflammation, and immunity
Entity
UAM. Departamento de Biología MolecularPublisher
MDPI (BASEL, SWITZERLAND)Date
2019-04-01Citation
10.3390/ijms20071626
International Journal of Molecular Sciences 20.7 (2019): 1626
ISSN
1661-6596 (print); 1422-0067 (online)DOI
10.3390/ijms20071626Funded by
This research was funded by grants from from “Ministerio de Ciencia e Innovación” (SAF2013-42850-R and SAF2016-75988-R) “Comunidad de Madrid” (S2017/BMD-3671. INFLAMUNE-CM), “Fondo de Investigaciones Sanitarias” (BIOIMID) to M.F. K.S. was recipient of a Spanish Association Against Cancer oncology investigator grant (AECC AIO)”.Project
Gobierno de España. SAF2013-42850-R; Gobierno de España. SAF2016-75988-R; Comunidad de Madrid. S2017/BMD-3671/ INFLAMUNEEditor's Version
https://doi.org/10.3390/ijms20071626Subjects
Cancer; DUSP10; Inflammation; MAPK; Biología y Biomedicina / BiologíaRights
© 2019 by the authors. Licensee MDPI, Basel, SwitzerlandAbstract
Cancer is one of the most diagnosed diseases in developed countries. Inflammation is a common response to different stress situations including cancer and infection. In those processes, the family of mitogen-activated protein kinases (MAPKs) has an important role regulating cytokine secretion, proliferation, survival, and apoptosis, among others. MAPKs regulate a large number of extracellular signals upon a variety of physiological as well as pathological conditions. MAPKs activation is tightly regulated by phosphorylation/dephosphorylation events. In this regard, the dual-specificity phosphatase 10 (DUSP10) has been described as a MAPK phosphatase that negatively regulates p38 MAPK and c-Jun N-terminal kinase (JNK) in several cellular types and tissues. Several studies have proposed that extracellular signal-regulated kinase (ERK) can be also modulated by DUSP10. This suggests a complex role of DUSP10 on MAPKs regulation and, in consequence, its impact in a wide variety of responses involved in both cancer and inflammation. Here, we review DUSP10 function in cancerous and immune cells and studies in both mouse models and patients that establish a clear role of DUSP10 in different processes such as inflammation, immunity, and cancer.
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Google Scholar:Jiménez-Martínez, Marta
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Stamatakis Andriani, Konstantinos
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Fresno Escudero, Manuel
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Centro de Biología Molecular Severo Ochoa (CBMSO)
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Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)
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