Copper(II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers
Entity
UAM. Departamento de Química InorgánicaPublisher
Wiley-VCH VerlagDate
2017-01-13Citation
10.1002/anie.201609031
Angewandte Chemie - International Edition 56.4 (2017): 987-991
ISSN
1521-3773 (online); 1433-7851 (print)DOI
10.1002/anie.201609031Funded by
Financial support from the Spanish Ministerio de Economía y Competitividad (MAT2016‐75883‐C2‐2‐P, MAT2016‐77608‐C3‐1‐P, MAT2013‐46502‐C2‐1P/2P, MAT2013‐46753‐C2‐1‐P, MAT2010‐20843‐C02‐01, SAF2014‐56763‐R), Asociación Española Contra el Cáncer, Generalitat Valenciana (PrometeoII/2014/076 and ISIC) and EU (FP6‐029192). R.L. thanks the Chilean Ministry of Education CONICYT (PhD Scholarship: BECA CHILE) for financial supportProject
Gobierno de España. MAT2016‐75883‐C2‐2‐P; Gobierno de España. MAT2016‐77608‐C3‐1‐P; Gobierno de España. MAT2013‐46502‐C2‐1P; Gobierno de España. MAT2013‐46502‐C2‐2P; Gobierno de España. MAT2013‐46753‐C2‐1‐P; Gobierno de España. MAT2010‐20843‐C02‐01; Gobierno de España. SAF2014‐56763‐R; info:eu-repo/grantAgreement/EC/FP6/029192Editor's Version
https://doi.org/10.1002/anie.201609031Subjects
Coordination polymers; Nanocarriers; Nanoribbons; Oligonucleotides; QuímicaNote
This is the peer reviewed version of the following article: Vegas, V. G., Lorca, R., Latorre, A., Hassanein, K., Gómez‐García, C. J., Castillo, O., ... & Amo‐Ochoa, P. (2017). Copper (II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers. Angewandte Chemie International Edition, 56(4), 987-991, which has been published in final form at https://doi.org/10.1002/anie.201609031. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsRights
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimAbstract
The direct reaction between copper nitrate, thymine-1-acetic acid, and 4,4′-bipyridine in water leads to the formation of a blue colloid comprising uniform crystalline nanoribbons (length >1 μm; width ca. 150–185 nm; diameter ca. 15–60 nm) of a coordination polymer. The polymer displays a thymine-based structure freely available for supramolecular interactions. These nanostructures show significant selective interaction with single-stranded oligonucleotides based on adenine. Remarkably, they present low cell toxicity in three cell lines–despite the copper(II) content–and can be used as nanocarriers of oligonucleotides. These results suggest the potential of these types of nanostructures in several biological applications
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Google Scholar:Vegas, Verónica G.
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Lorca, Romina
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Latorre, Ana
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Hassanein, Khaled
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Gómez-García, Carlos J.
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Castillo, Oscar
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Somoza, Álvaro
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Zamora, Félix
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Amo-Ochoa, Pilar
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