Copper(II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers
Metadatos
Title:
Copper(II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers
Author:
Vegas, Verónica G.; Lorca, Romina; Latorre, Ana; Hassanein, Khaled; Gómez-García, Carlos J.; Castillo, Oscar; Somoza, Álvaro; Zamora, Félix; Amo-Ochoa, Pilar
Entity:
UAM. Departamento de Química Inorgánica
UAM Author:
García Vegas, Verónica
; Hassanein Sayed Ahmed, Khaled
; Gómez García, Carlos
; Zamora Abanades, Félix Juan
; Amo Ochoa, María Pilar
Publisher:
Wiley-VCH Verlag
Date:
2017-01-13
Citation:
10.1002/anie.201609031
Angewandte Chemie - International Edition 56.4 (2017): 987-991
ISSN:
1521-3773 (online); 1433-7851 (print)
DOI:
10.1002/anie.201609031
Funded by:
Financial support from the Spanish Ministerio de Economía y Competitividad (MAT2016‐75883‐C2‐2‐P, MAT2016‐77608‐C3‐1‐P, MAT2013‐46502‐C2‐1P/2P, MAT2013‐46753‐C2‐1‐P, MAT2010‐20843‐C02‐01, SAF2014‐56763‐R), Asociación Española Contra el Cáncer, Generalitat Valenciana (PrometeoII/2014/076 and ISIC) and EU (FP6‐029192). R.L. thanks the Chilean Ministry of Education CONICYT (PhD Scholarship: BECA CHILE) for financial support
Project:
Gobierno de España. MAT2016‐75883‐C2‐2‐P; Gobierno de España. MAT2016‐77608‐C3‐1‐P; Gobierno de España. MAT2013‐46502‐C2‐1P; Gobierno de España. MAT2013‐46502‐C2‐2P; Gobierno de España. MAT2013‐46753‐C2‐1‐P; Gobierno de España. MAT2010‐20843‐C02‐01; Gobierno de España. SAF2014‐56763‐R; info:eu-repo/grantAgreement/EC/FP6/029192
Editor's Version:
https://doi.org/10.1002/anie.201609031
Subjects:
Coordination polymers; Nanocarriers; Nanoribbons; Oligonucleotides; Química
Note:
This is the peer reviewed version of the following article:
Vegas, V. G., Lorca, R., Latorre, A., Hassanein, K., Gómez‐García, C. J., Castillo, O., ... & Amo‐Ochoa, P. (2017). Copper (II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers. Angewandte Chemie International Edition, 56(4), 987-991,
which has been published in final form at https://doi.org/10.1002/anie.201609031.
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
Rights:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Abstract:
The direct reaction between copper nitrate, thymine-1-acetic acid, and 4,4′-bipyridine in water leads to the formation of a blue colloid comprising uniform crystalline nanoribbons (length >1 μm; width ca. 150–185 nm; diameter ca. 15–60 nm) of a coordination polymer. The polymer displays a thymine-based structure freely available for supramolecular interactions. These nanostructures show significant selective interaction with single-stranded oligonucleotides based on adenine. Remarkably, they present low cell toxicity in three cell lines–despite the copper(II) content–and can be used as nanocarriers of oligonucleotides. These results suggest the potential of these types of nanostructures in several biological applications
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