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dc.contributor.authorVegas, Verónica G.
dc.contributor.authorLorca, Romina
dc.contributor.authorLatorre, Ana
dc.contributor.authorHassanein, Khaled
dc.contributor.authorGómez-García, Carlos J.
dc.contributor.authorCastillo, Oscar
dc.contributor.authorSomoza, Álvaro
dc.contributor.authorZamora, Félix
dc.contributor.authorAmo-Ochoa, Pilar
dc.contributor.otherUAM. Departamento de Química Inorgánicaes_ES
dc.date.accessioned2019-10-16T13:54:51Z
dc.date.available2019-10-16T13:54:51Z
dc.date.issued2017-01-13
dc.identifier.citationAngewandte Chemie - International Edition 56.4 (2017): 987-991en_US
dc.identifier.issn1521-3773 (online)en_US
dc.identifier.issn1433-7851 (print)en_US
dc.identifier.urihttp://hdl.handle.net/10486/688865
dc.descriptionThis is the peer reviewed version of the following article: Vegas, V. G., Lorca, R., Latorre, A., Hassanein, K., Gómez‐García, C. J., Castillo, O., ... & Amo‐Ochoa, P. (2017). Copper (II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers. Angewandte Chemie International Edition, 56(4), 987-991, which has been published in final form at https://doi.org/10.1002/anie.201609031. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versionsen_US
dc.description.abstractThe direct reaction between copper nitrate, thymine-1-acetic acid, and 4,4′-bipyridine in water leads to the formation of a blue colloid comprising uniform crystalline nanoribbons (length >1 μm; width ca. 150–185 nm; diameter ca. 15–60 nm) of a coordination polymer. The polymer displays a thymine-based structure freely available for supramolecular interactions. These nanostructures show significant selective interaction with single-stranded oligonucleotides based on adenine. Remarkably, they present low cell toxicity in three cell lines–despite the copper(II) content–and can be used as nanocarriers of oligonucleotides. These results suggest the potential of these types of nanostructures in several biological applicationsen_US
dc.description.sponsorshipFinancial support from the Spanish Ministerio de Economía y Competitividad (MAT2016‐75883‐C2‐2‐P, MAT2016‐77608‐C3‐1‐P, MAT2013‐46502‐C2‐1P/2P, MAT2013‐46753‐C2‐1‐P, MAT2010‐20843‐C02‐01, SAF2014‐56763‐R), Asociación Española Contra el Cáncer, Generalitat Valenciana (PrometeoII/2014/076 and ISIC) and EU (FP6‐029192). R.L. thanks the Chilean Ministry of Education CONICYT (PhD Scholarship: BECA CHILE) for financial supporten_US
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherWiley-VCH Verlagen_US
dc.relation.ispartofAngewandte Chemie - International Editionen_US
dc.rights© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheimen_US
dc.subject.otherCoordination polymersen_US
dc.subject.otherNanocarriersen_US
dc.subject.otherNanoribbonsen_US
dc.subject.otherOligonucleotidesen_US
dc.titleCopper(II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriersen_US
dc.typearticleen
dc.subject.ecienciaQuímicaes_ES
dc.date.embargoend2018-01-13
dc.relation.publisherversionhttps://doi.org/10.1002/anie.201609031es_ES
dc.identifier.doi10.1002/anie.201609031es_ES
dc.identifier.publicationfirstpage987es_ES
dc.identifier.publicationissue4es_ES
dc.identifier.publicationlastpage991es_ES
dc.identifier.publicationvolume56es_ES
dc.relation.projectIDGobierno de España. MAT2016‐75883‐C2‐2‐Pes_ES
dc.relation.projectIDGobierno de España. MAT2016‐77608‐C3‐1‐Pes_ES
dc.relation.projectIDGobierno de España. MAT2013‐46502‐C2‐1Pes_ES
dc.relation.projectIDGobierno de España. MAT2013‐46502‐C2‐2Pes_ES
dc.relation.projectIDGobierno de España. MAT2013‐46753‐C2‐1‐Pes_ES
dc.relation.projectIDGobierno de España. MAT2010‐20843‐C02‐01es_ES
dc.relation.projectIDGobierno de España. SAF2014‐56763‐Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP6/029192en_US
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.rights.accessRightsopenAccessen
dc.authorUAMGarcía Vegas, Verónica (314148)
dc.authorUAMHassanein Sayed Ahmed, Khaled (264971)
dc.authorUAMGómez García, Carlos (260477)
dc.authorUAMZamora Abanades, Félix Juan (258846)
dc.authorUAMAmo Ochoa, María Pilar (261554)
dc.facultadUAMFacultad de Ciencias


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