CD30-positive primary cutaneous lymphoproliferative disorders: Molecular alterations and targeted therapies
Entity
UAM. Departamento de Anatomía Patológica; UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Publisher
Ferrata Storti FoundationDate
2019-01-31Citation
10.3324/haematol.2018.197152
Haematologica 104.2 (2019): 226-235
ISSN
0390-6078 (print); 1592-8721 (online)DOI
10.3324/haematol.2018.197152Funded by
This work was supported by grants from the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Economy and Competence (MINECO, RTICC ISCIII and CIBERONC) (SAF2013-47416-R, RD06/0020/0107-RD012/0036/0060 and Plan Nacional I+D+I: PI17/2172, PI16/01294 and PIE15/0081), AECC and the Madrid Autonomous Community.Project
Gobierno de España. SAF2013-47416-R; Gobierno de España. RD06/0020/0107; Gobierno de España. RD012/0036/0060; Gobierno de España. PI17/2172; Gobierno de España. PI16/01294; Gobierno de España. PIE15/0081Editor's Version
https://doi.org/10.3324/haematol.2018.197152Subjects
CD30-positive; T-cell; Lymphoproliferative; Cutaneous; Molecular alterations; MedicinaRights
© 2019 Ferrata Storti FoundationAbstract
Primary cutaneous CD30-positive T-cell lymphoproliferative disorders are the second most common subgroup of cutaneous T-cell lymphomas. They include two clinically different entities with some overlapping features and borderline cases: lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma. Molecular studies of primary cutaneous anaplastic large cell lymphoma reveal an increasing level of heterogeneity that is associated with histological and immunophenotypic features of the cases and their response to specific therapies. Here, we review the most significant genetic, epigenetic and molecular alterations described to date in primary cutaneous CD30-positive T-cell lymphoproliferative disorders, and their potential as therapeutic targets.
Files in this item
Google Scholar:Prieto-Torres, Lucia
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Rodriguez-Pinilla, Socorro M.
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Onaindia, Arantza
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Ara, Mariano
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Requena Caballero, Luis
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Piris, Miguel
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