Clinical and molecular comparative study of colorectal cancer based on age-of-onset and tumor location: Two main criteria for subclassifying colorectal cancer
Author
Álvaro, Edurne; Cano, Juana M.; García, Juan L.; Brandáriz, Lorena; Olmedillas-López, Susana; Arriba, María; Rueda, Daniel; Rodríguez, Yolanda; Cañete, Ángel; Arribas, Julia; Inglada-Pérez, Lucía; Pérez, Jessica; Gómez, Carlos; García Arranz, Mariano Andrés; García Olmo, Damián; Goel, Ajay; Urioste, Miguel; González-Sarmiento, Rogelio; Perea, JoséEntity
UAM. Departamento de Cirugía; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Publisher
MDPI, Basel, SwitzerlandDate
2019-02-22Citation
10.3390/ijms20040968
International Journal of Molecular Sciences 20.4 (2019): 968
ISSN
1661-6596 (print); 1422-00678 (online)DOI
10.3390/ijms20040968Funded by
This work was funded by Project PI10/0683 and PI13/0127 and PI16/01650 to J.P, and PI16/01920 to R.G.S, and PI17/01233 to D.G-O from the Spanish Ministry of Health and Consumer Affairs, and co-funded by the European Regional Development Fund (FEDER); and supported by grants R01 CA72851, CA18172, CA184792, and U01 CA187956 from the National Cancer Institute, National Institutes of Health to Ajay GoelProject
Gobierno de España. PI17/01233Editor's Version
https://doi.org/10.3390/ijms20040968Subjects
Chromosomal instability; CpG island methylator phenotype; Early-onset colorectal cancer; Late-onset colorectal cancer; Microsatellite instability; Tumor location; MedicinaRights
© 2019 by the authorsAbstract
Our aim was to characterize and validate that the location and age of onset of the tumor are both important criteria to classify colorectal cancer (CRC). We analyzed clinical and molecular characteristics of early-onset CRC (EOCRC) and late-onset CRC (LOCRC), and we compared each tumor location between both ages-of-onset. In right-sided colon tumors, early-onset cases showed extensive Lynch syndrome (LS) features, with a relatively low frequency of chromosomal instability (CIN), but a high CpG island methylation phenotype. Nevertheless, late-onset cases showed predominantly sporadic features and microsatellite instability cases due to BRAF mutations. In left colon cancers, the most reliable clinical features were the tendency to develop polyps as well as multiple primary CRC associated with the late-onset subset. Apart from the higher degree of CIN in left-sided early-onset cancers, differential copy number alterations were also observed. Differences among rectal cancers showed that early-onset rectal cancers were diagnosed at later stages, had less association with polyps, and more than half of them were associated with a familial LS component. Stratifying CRC according to both location and age-of-onset criteria is meaningful, not only because it correlates the resulting categories with certain molecular bases, but with the confirmation across larger studies, new therapeutical algorithms could be defined according to this subclassification.
Files in this item
Google Scholar:Álvaro, Edurne
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Cano, Juana M.
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García, Juan L.
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Brandáriz, Lorena
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Olmedillas-López, Susana
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Arriba, María
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Rueda, Daniel
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Rodríguez, Yolanda
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Cañete, Ángel
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Arribas, Julia
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Inglada-Pérez, Lucía
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Pérez, Jessica
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Gómez, Carlos
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García Arranz, Mariano Andrés
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García Olmo, Damián
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Goel, Ajay
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Urioste, Miguel
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González-Sarmiento, Rogelio
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Perea, José
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