Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain: The SEPAR National Registry
Author
Fernández-Fabrellas, Estrella; Molina-Molina, María; Soriano, Joan B.; Rodríguez Portal, José Antonio; Ancochea Bermúdez, Julio


Entity
UAM. Departamento de MedicinaPublisher
BMC (part of Springer Nature)Date
2019-06-17Citation
10.1186/s12931-019-1084-0
Respiratory Research 20.1 (2019): 127
ISSN
1465-9921 (print); 1465-993X (online)DOI
10.1186/s12931-019-1084-0Funded by
This study was funded by Roche Farma SA Spain.Editor's Version
https://doi.org/10.1186/s12931-019-1084-0Subjects
Anti-fibrotic treatment; Idiopathic pulmonary fibrosis; National registry; SEPAR; Spain; MedicinaRights
© 2019 The Author(s).Abstract
Background: Little is known on the characteristics of patients diagnosed with idiopathic pulmonary fibrosis (IPF) in Spain. We aimed to characterize the demographic and clinical profile of IPF patients included in the IPF National Registry of the Spanish Respiratory Society (SEPAR). Methods: This is a prospective, observational, multicentre and nationwide study that involved 608 IPF patients included in the SEPAR IPF Registry up to June 27th, 2017, and who received any treatment for their disease. IPF patients were predominantly males, ex-smokers, and aged in their 70s, similar to other registries. Results: Upon inclusion, mean ± SD predicted forced vital capacity was 77.6% ± 19.4, diffusing capacity for carbon monoxide was 48.5% ± 17.7, and the 6-min walk distance was 423.5 m ± 110.4. The diagnosis was mainly established on results from the high-resolution computed tomography in the proper clinical context (55.0% of patients), while 21.2% of patients required invasive procedures (surgical lung biopsy) for definitive diagnosis. Anti-fibrotic treatment was prescribed in 69.4% of cases, 51.5% pirfenidone and 17.9% nintedanib, overall with a good safety profile. Conclusions: The SEPAR IPF Registry should help to further characterize current characteristics and future trends of IPF patients in Spain and compare/pool them with other registries and cohorts.
Files in this item
Google Scholar:Fernández-Fabrellas, Estrella
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Molina-Molina, María
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Soriano, Joan B.
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Rodríguez Portal, José Antonio
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Ancochea Bermúdez, Julio
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Valenzuela, Claudia
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Xaubet, Antoni
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Aburto Barrenetxea, M.
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Alfageme Michavila, I.
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Bollo De Miguel, E.
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Cano, E.
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Casanova Espinosa, A.
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Castillo Villegas, D.
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Figuerola Mendal, J. A.
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García Sevila, R.
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Gaudó Navarro, J. I.
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Gómez Carrera, Luis
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González, J. M.
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Herrera Lara, S.
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Laporta Hernández, R.
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Marín González, M.
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Nieto Barbero, M. A.
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Portillo, K.
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Romero, A. D.
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Sánchez Simón-Talero, R.
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Sancho Chust, J. N.
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Sellarés Torres, J.
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Soler Sempere, M. J.
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Sauleda Roig, J.
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Tomás López, L.
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Villanueva Montes, M.
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