HIV coinfection predicts failure of ledipasvir/sofosbuvir in treatment-naïve noncirrhotic patients with HCV genotype

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Show simple item record Berenguer, Juan Calleja, José Luis Montes, María Luisa Gil, Ángela Moreno, Ana Bañares, Rafael Aldámiz-Echevarría, Teresa Albillos, Agustín Téllez, María Jesús Olveira, Antonio Domínguez, Lourdes Fernández, Inmaculada García-Samaniego, Javier Polo, Benjamín A. Álvarez, Beatriz Ryan, Pablo Barrio, José Devesa, María J. Benítez, Laura Santos, Ignacio Buey, Luisa García Sanz, José Poves, Elvira Losa, Juan E. Fernández-Rodríguez, Conrado Jarrín, Inmaculada Calvo, María J. González-García, Juan
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.contributor.other Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) es_ES 2019-11-05T18:12:16Z 2019-11-05T18:12:16Z 2019-05-01
dc.identifier.citation Open Forum Infectious Diseases 6.5 (2019): 1-10 en_US
dc.identifier.issn 2328-8957 es_ES
dc.description.abstract The efficacy of licensed direct-acting antiviral (DAA) regimens is assumed to be the same for hepatitis C virus (HCV)–monoinfected patients (HCV-Mono) and HIV/HCV-coinfected patients (HCV-Co). However, the high sustained viral response (SVR) rates of DAA regimens and the small number of HIV-infected patients included in registration trials have made it difficult to identify predictors of treatment failure, including the presence of HIV. Methods. We compared treatment outcomes for ledipasvir/sofosbuvir (LDV/SOF) against HCV G1 in treatment-naïve HCV-Mono and HCV-Co without cirrhosis in a prospective registry of individuals receiving DAAs for HCV. Results. Up to September 2017, a total of 17 269 patients were registered, and 1358 patients (1055 HCV-Mono/303 HCV-Co) met the inclusion criteria. Significant differences between HCV-Mono and HCV-Co were observed for age, gender, and G1 subtype distribution. Among HCV-Co, 99.0% were receiving antiretroviral therapy. SVR rates for LDV/SOF at 8 weeks did not differ significantly between HCV-Mono and HCV-Co (96.9% vs 94.0%; P = .199). However, the SVR rate for LDV/SOF at 12 weeks was significantly higher for HCV-Mono than HCV-Co (97.2% vs 91.8%; P = .001). A multivariable logistic regression model including age, sex, liver stiffness, G1 subtype, HCV-RNA, HIV, and treatment duration showed the factors associated with treatment failure to be male sex (adjusted odds ratio [aOR], 2.49; 95% confidence interval [CI], 1.27–4.91; P = .008) and HIV infection (aOR, 2.23; 95% CI, 1.13–4.38; P = .020). Conclusions. The results of this large prospective study analyzing outcomes for LDV/SOF against HCV G1 in treatment-naïve noncirrhotic patients suggest that HIV infection is a predictor of treatment failure in patients with chronic hepatitis C. en_US
dc.description.sponsorship This work was supported by the Spanish AIDS Research Network (RD16/0025/0017), which is included in the Spanish I+D+I Plan and is co-financed by ISCIII-Subdirección General de Evaluacion and European Funding for Regional Development (FEDER), and the Fondo de Investigación de Sanidad en España (FIS)/Instituto de Salud Carlos III (Spanish Health Research Funds; PI17/00657). en_US
dc.format.extent 10 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Oxford University Press on behalf of Infectious Diseases Society of America en_US
dc.relation.ispartof Open Forum Infectious Diseases en_US
dc.rights © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. Background. en_US
dc.subject.other Antiviral agents/administration & dosage/*therapeutic use en_US
dc.subject.other DAA en_US
dc.subject.other Hepatitis C, chronic/*complications/*drug therapy en_US
dc.subject.other HIV infections/*complications en_US
dc.subject.other Sustained virologic response en_US
dc.title HIV coinfection predicts failure of ledipasvir/sofosbuvir in treatment-naïve noncirrhotic patients with HCV genotype en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion es_ES
dc.identifier.doi 10.1093/ofid/ofz214 es_ES
dc.identifier.publicationfirstpage 1 es_ES
dc.identifier.publicationissue 5 es_ES
dc.identifier.publicationlastpage 10 es_ES
dc.identifier.publicationvolume 6 es_ES
dc.relation.projectID Gobierno de España. RD16/0025/0017 es_ES
dc.relation.projectID Gobierno de España. PI17/00657 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en Reconocimiento – NoComercial – SinObraDerivada es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Calleja Panero, José Luis (101541)
dc.authorUAM González García, Juan Julián (258399)

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