Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system
EntityUAM. Departamento de Biología
PublisherPublic Library of Science
10.1371/journal.pone.0194281PLoS ONE 13.4 (2018): e0194281
Funded byThis study was supported by grant number: BFU2013-43858-P
ProjectGobierno de España. BFU2013-43858-P
SubjectsNeuronal differentiation; Neurons; Drosophila melanogaster; Embryos; Neuroblasts; Nervous system; Apoptosis; Central nervous system; Biología y Biomedicina / Biología
Rights© 2018 Gabilondo et al.
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In this study, we identify the means by which segmentally homologous neurons acquire different neuropeptide fates in Drosophila. Ventral abdominal (Va)-neurons in the A1 segment of the ventral nerve cord express DH31 and AstA neuropeptides (neuropeptidergic fate I) by virtue of Ubx activity, whereas the A2-A4 Va-neurons express the Capa neuropeptide (neuropeptidergic fate II) under the influence of abdA. These different fates are attained through segment-specific programs of neural subtype specification undergone by segmentally homologous neurons. This is an attractive alternative by which Hox genes can shape Drosophila segmental neural architecture (more sophisticated than the previously identified binary “to live” or “not to live” mechanism). These data refine our knowledge of the mechanisms involved in diversifying neuronal identity within the central nervous system
Google Scholar:Gabilondo, Hugo - Rubio-Ferrera, Irene - Losada-Pérez, María - Del Saz, Delia - León Álvarez, Yolanda - Molina Balsa, Isabel - Torroja, Laura - Allan, Douglas W. - Benito Sipos, Jonathan
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