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Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system

Author
Gabilondo, Hugo; Rubio-Ferrera, Irene; Losada-Pérez, María; Del Saz, Delia; León Álvarez, Yolandauntranslated; Molina Balsa, Isabeluntranslated; Torroja, Laura; Allan, Douglas W.; Benito Sipos, Jonathanuntranslated
Entity
UAM. Departamento de Biología
Publisher
Public Library of Science
Date
2018-04-01
Citation
10.1371/journal.pone.0194281
PLoS ONE 13.4 (2018): e0194281
 
 
 
ISSN
1932-6203
DOI
10.1371/journal.pone.0194281
Funded by
This study was supported by grant number: BFU2013-43858-P
Project
Gobierno de España. BFU2013-43858-P
Editor's Version
https://doi.org/10.1371/journal.pone.0194281
Subjects
Neuronal differentiation; Neurons; Drosophila melanogaster; Embryos; Neuroblasts; Nervous system; Apoptosis; Central nervous system; Biología y Biomedicina / Biología
URI
http://hdl.handle.net/10486/690329
Rights
© 2018 Gabilondo et al.

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In this study, we identify the means by which segmentally homologous neurons acquire different neuropeptide fates in Drosophila. Ventral abdominal (Va)-neurons in the A1 segment of the ventral nerve cord express DH31 and AstA neuropeptides (neuropeptidergic fate I) by virtue of Ubx activity, whereas the A2-A4 Va-neurons express the Capa neuropeptide (neuropeptidergic fate II) under the influence of abdA. These different fates are attained through segment-specific programs of neural subtype specification undergone by segmentally homologous neurons. This is an attractive alternative by which Hox genes can shape Drosophila segmental neural architecture (more sophisticated than the previously identified binary “to live” or “not to live” mechanism). These data refine our knowledge of the mechanisms involved in diversifying neuronal identity within the central nervous system
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Google™ Scholar:Gabilondo, Hugo - Rubio-Ferrera, Irene - Losada-Pérez, María - Del Saz, Delia - León Álvarez, Yolanda - Molina Balsa, Isabel - Torroja, Laura - Allan, Douglas W. - Benito Sipos, Jonathan

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  • Producción científica en acceso abierto de la UAM [16522]

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All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
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