Simulating evolution in asexual populations with epistasis
Author
Díaz Uriarte, RamónEntity
UAM. Departamento de BioquímicaPublisher
Humana, New YorkDate
2021-03-01Citation
10.1007/978-1-0716-0947-7_9
Díaz-Uriarte, Ramón. "Simulating evolution in asexual populations with epistasis". Epistasis: Methods and protocols. Methods in molecular biology. Ed. KC. Wong, Volume 2212. New York: Humana, 2021. 121-154
ISBN
978-1-0716-0946-0 (print); 978-1-0716-0947-7 (online)DOI
10.1007/978-1-0716-0947-7_9Funded by
Supported by BFU2015-67302-R (MINECO/FEDER, EU) to RDUProject
Gobierno de España. BFU2015-67302-REditor's Version
https://doi.org/10.1007/978-1-0716-0947-7_9Subjects
simulation; epistasis; fitness landscape; evolution; mutation; fitness; Biología y Biomedicina / BiologíaRights
© The Author(s) 2021Abstract
I show how to use OncoSimulR, software for forward-time genetic simulations, to simulate evolution
of asexual populations in the presence of epistatic interactions. This chapter emphasizes the
specification of fitness and epistasis, both directly (i.e., specifying the effects of individual mutations
and their epistatic interactions) and indirectly (using models for random fitness landscapes)
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