Born too early and too small: higher order cognitive function and brain at risk at ages 8–16
Entity
UAM. Departamento de Psicología Evolutiva y de la EducaciónPublisher
Frontiers MediaDate
2019-09-06Citation
10.3389/fpsyg.2019.01942
Front. Psychol. 10 (2019): 1942
ISSN
1664-1078DOI
10.3389/fpsyg.2019.01942Funded by
This study was supported by the Spanish Government Institute Carlos III (FIS Pl11/02860), Spanish Ministry of Health to MM-L, and the University of Castilla-La Mancha mobility Grant VA13815001497Project
Gobierno de España. FIS Pl11/02860Editor's Version
http://doi.org/10.3389/fpsyg.2019.01942Subjects
preterm; perinatal clinical variables; cognition; MRI; DTI; cognitive function; fornix; memory; PsicologíaRights
Copyright © 2019 Córcoles-Parada, Giménez-Mateo, Serrano-del-Pueblo, López, Pérez-Hernández, Mansilla, Martínez, Onsurbe, San Roman, Ubero-Martinez, Clayden, Clark and Muñoz-LópezAbstract
Prematurity presents a risk for higher order cognitive functions. Some of these deficits
manifest later in development, when these functions are expected to mature. However,
the causes and consequences of prematurity are still unclear. We conducted a
longitudinal study to first identify clinical predictors of ultrasound brain abnormalities in
196 children born very preterm (VP; gestational age 32 weeks) and with very low birth
weight (VLBW; birth weight 1500 g). At ages 8–16, the subset of VP-VLBW children
without neurological findings (124) were invited for a neuropsychological assessment
and an MRI scan (41 accepted). Of these, 29 met a rigorous criterion for MRI quality
and an age, and gender-matched control group (n = 14) was included in this study.
The key findings in the VP-VLBW neonates were: (a) 37% of the VP-VLBW neonates
had ultrasound brain abnormalities; (b) gestational age and birth weight collectively with
hospital course (i.e., days in hospital, neonatal intensive care, mechanical ventilation and
with oxygen therapy, surgeries, and retinopathy of prematurity) predicted ultrasound
brain abnormalities. At ages 8–16, VP-VLBW children showed: a) lower intelligent
quotient (IQ) and executive function; b) decreased gray and white matter (WM) integrity;
(c) IQ correlated negatively with cortical thickness in higher order processing cortical
areas. In conclusion, our data indicate that facets of executive function and IQ are the
most affected in VP-VLBW children likely due to altered higher order cortical areas and
underlying WM
Files in this item
Google Scholar:Córcoles Parada, Marta
-
Giménez Mateo, Rocío
-
Serrano del Pueblo, Víctor
-
López, Leidy
-
Pérez Hernández, Elena
-
Mansilla, Francisco
-
Martínez, Andrés
-
Onsurbe, Ignacio
-
San Román, Paloma
-
Ubero Martínez, Mar
-
Clayden, Jonathan D.
-
Clark, Chris A.
-
Muñoz López, Mónica
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease
Escott-Price, Valentina; Bellenguez, Céline; Wang, Lisan; Choi, Seunghoan; Harold, Denise H.; Jones, Lesley A.; Holmans, Peter A.; Gerrish, Amy; Vedernikov, Alexey; Richards, Alexander L.; Destefano, Anita L.; Lambert, Jean Charles; Ibrahim-Verbaas, Carla A.; Naj, Adam C.; Sims, Rebecca J A; Jun, Gyungah; Bis, Joshua C M; Beecham, Gary W.; Grenier-Boley, Benjamin; Russo, Giancarlo Carlo; Thornton-Wells, Tricia A.; Denning, Nicola; Smith, Albert Vernon; Chouraki, Vincent; Thomas, Charlene; Arfan Ikram, M.; Zélénika, Diana; Vardarajan, Badri Narayan; Kamatani, Yoichiro; Lin, Chiaofeng; Schmidt, Helena; Kunkle, Brian W.; Dunstan, Melanie L.; Vronskaya, Maria; Johnson, Andrew D.; Ruíz, Agustín R.; Bihoreau, Marie Thérèse; Reitz, Christiane; Pasquier, Florence; Hollingworth, Paul; Hanon, Olivier; Fitzpatrick, Annette L.; Buxbaum, Joseph D.; Campion, Dominique; Crane, Paul K.; Becker, Clinton Baldwin Tim; Gudnason, Vilmundur G.; Cruchaga, Carlos; Craig, David A.; Amin, Najaf; Berr, Claudine; López, Óscar L.; De Jager, Philip L.; Deramecourt, Vincent; Johnston, Janet A.; Evans, Denis Andrew; Lovestone, Simon; Letenneur, Luc U C; Hernández, Isabel Martínez; Rubinsztein, David C.; Eiríksdóttir, Gudný; Sleegers, Kristel; Goate, Alison M.; Fiévet, Nathalie; Huentelman, Matthew J J.; Gill, Michael; Brown, Kristelle S.; Kamboh, Mohammad Ilyas; Keller, Lina; Barberger-Gateau, Pascale; McGuinness, Bernadette M.; Larson, Eric B.; Myers, Amanda J.; Dufouil, Carole; Todd, Stephen A.; Wallon, David; Love, Seth; Rogaeva, Ekaterina A.; Gallacher, John E J; St. George-Hyslop, Peter; Clarimon, Jordi; Lleõ, Alberto; Bayer, A.; Tsuang, Debby W.; Yu, Lei; Tsolaki, Magda N.; Bossù, Paola; Spalletta, Gianfranco; Proitsi, Petra; Collinge, John C.; Sorbi, Sandro; Sánchez-García, Florentino; Fox, Nick C.; Hardy, John Anthony; Naranjo, Maria Candida Deniz; Bosco, Paolo; Clarke, Robert J.; Brayne, Carol E G; Galimberti, Daniela; Scarpini, Elio A.; Bonuccelli, Ubaldo; Mancuso, Michelangelo; Siciliano, Gabriele; Moebus, Susanne; Mecocci, Patrizia; Del Zompo, M.; Maier, Wolfgang A.; Hampel, Harald; Pilotto, Alberto; Frank García, Ana; Panza, Francesco; Solfrizzi, Vincenzo; Caffarra, Paolo; Nacmias, B.; Perry, William Lloyd; Mayhaus, Manuel; Lannfelt, Lars; Hákonarson, Hákon H.; Pichler, Sabrina; Carrasquillo, Minerva M.; Ingelsson, Martin; Beekly, Duane L.; Álvarez, Victoria Asensi; Zou, Fanggeng; Valladares, Otto; Younkin, Steven G.; Coto, Eliécer; Hamilton-Nelson, Kara L.; Gu, Wei; Razquin, Cristina; Pastor, Pau; Mateo, Ignacio; Owen, Michael John; Faber, Kelley M.; Jónsson, Pálmi Válmi; Combarros, Onofre; O'Donovan, M. C.; Cantwell, Laura B.; Soininen, Hilkka S.; Blacker, Deborah L.; Mead, Simon H.; Mosley, Thomas H.; Bennett, David Alan; Harris, Tamara B.; Fratiglioni, Laura; Holmes, Clive A.; De Bruijn, Renée Fag A G; Passmore, Peter A.; Montine, Thomas J.; Bettens, Karolien; Rotter, Jerome I.; Brice, Alexis; Morgan, Kevin N.; Foroud, Tatiana M.; Kukull, Walter A.; Hannequin, Didier; Powell, John F F; Nalls, Michael A.; Ritchie, Karen Anne; Lunetta, Kathryn L.; Kauwe, John S K; Boerwinkle, Eric Eric; Riemenschneider, Matthias; Boada, Merçé; Hiltunen, Mikko J.; Martin, Eden R.; Schmidt, Reinhold Ernst S; Rujescu, Dan A N; Dartigues -, Jean François; Mayeux, Richard P.; Tzourio, Christophe; Hofman, Albert; Nöthen, Markus M.; Graff, Caroline; Psaty, Bruce M.; Haines, Jonathan L.; Lathrop, Mark G.; Peričak-Vance, Margaret A O; Launer, Lenore J.; Van Broeckhoven, Christine L.; Farrer, Lindsay A A.; Van Duijn, Cornélia M.; Ramírez, Alfredo L.; Seshadri, Sudha; Schellenberg, Gerard David; Amouyel, Philippe; Williams, Julie I.
2014-06-12 -
Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study
Mallorquí-Bagué, Núria; Lozano-Madrid, María; Toledo, Estefanía; Corella, Dolores; Salas-Salvadó, Jordi; Cuenca-Royo, Aida; Vioque, Jesús; Romaguera, Dora; Martínez, J. Alfredo; Wärnberg, Julia; López-Miranda, José; Estruch, Ramón; Bueno-Cavanillas, Aurora; Alonso-Gómez, Ángel; Tur, Josep A.; Tinahones, Francisco J.; Serra-Majem, Lluís; Martín, Vicente; Lapetra, José; Vázquez, Clotilde; Pintó, Xavier; Vidal, Josep; Daimiel, Lidia; Gaforio, José J.; Matía, Pilar; Ros, Emilio; Granero, Roser; Buil-Cosiales, Pilar; Barragán, Rocío; Bulló, Mònica; Castañer, Olga; García-de-la-Hera, Manoli; Yáñez, Aina M.; Abete, Itziar; García-Ríos, Antonio; Ruiz-Canela, Miguel; Díaz-López, Andrés; Jiménez-Murcia, Susana; Martínez-González, Miguel Ángel; De la Torre, Rafael; Fernández-Aranda, Fernando
2018-10-31