Effects of arachidonic and docosohexahenoic acid supplementation during gestation in rats. implication of placental oxidative stress
Author
Reyes-Hernández, Cynthia Guadalupe; Ramiro-Cortijo, David; Rodríguez-Rodríguez, Pilar; Giambelluca, Sonia; Simonato, Manuela; González Enguita, María del Carmen



Entity
UAM. Departamento de Fisiología; UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología; UAM. Departamento de PediatríaPublisher
MDPIDate
2018-12-04Citation
10.3390/ijms19123863
Int. J. Mol. Sci. 19.12 (2018): 3863
ISSN
1661-6596 (print); 1422-0067 (online)DOI
10.3390/ijms19123863Funded by
This work was supported by the Ministerio de Economía y Competitividad (Spain) PN I + D + I [grant numbers FEM2015-63631-R; 2015] co-financed with FEDER fundsProject
Gobierno de España. FEM2015-63631-REditor's Version
https://doi.org/10.3390/ijms19123863.Subjects
ARA; DHA; oxidative stress; IUGR; fetus; placenta; MedicinaRights
© 2018 by the authorsAbstract
Arachidonic and docosahexaenoic acids (ARA and DHA) are important during pregnancy.
However, the effects of dietary supplementation on fetal growth and oxidative stress are inconclusive.
We aimed to assess the effect of high ARA and DHA diet during rat gestation on: (1) ARA and DHA
availability in plasma and placenta, (2) fetal growth, and (3) placental oxidative stress, analyzing
the influence of sex. Experimental diet (ED) was prepared by substituting soybean oil in the control
diet (CD) by a fungi/algae-based oil containing ARA and DHA (2:1). Rats were fed with CD or ED
during gestation; plasma, placenta, and fetuses were obtained at gestational day 20. DHA, ARA,
and their precursors were analyzed in maternal plasma and placenta by gas chromatography/mass
spectrophotometry. Fetuses and placentas were weighed, the proportion of fetuses with intrauterine
growth restriction (IUGR) determined, and placental lipid and protein oxidation analyzed. ED fetuses
exhibited lower body weight compared to CD, being >40% IUGR; fetal weight negatively correlated
with maternal plasma ARA, but not DHA. Only ED female placenta exhibited higher lipid and
protein oxidation compared to its CD counterparts; lipid peroxidation is negatively associated with
fetal weight. In conclusion, high ARA during gestation associates with IUGR, through placental
oxidative stress, with females being more susceptible
Files in this item
Google Scholar:Reyes-Hernández, Cynthia Guadalupe
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Ramiro-Cortijo, David
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Rodríguez-Rodríguez, Pilar
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Giambelluca, Sonia
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Simonato, Manuela
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González Enguita, María del Carmen
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López de Pablo León, Ángel Luis
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López-Giménez, M. del Rosario
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Cogo, Paola
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Sáenz de Pipaón Marcos, Miguel
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Carnielli, Virgilio P.
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Arribas Rodríguez, Silvia Magdalena
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