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G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub

dc.contributor.authorPenela Márquez, Petronila 
dc.contributor.authorRibas Núñez, Catalina 
dc.contributor.authorSánchez Madrid, Francisco 
dc.contributor.authorMayor Menéndez, Federico 
dc.contributor.otherUAM. Departamento de Biología Moleculares_ES
dc.date.accessioned2020-04-29T10:50:34Z
dc.date.available2020-04-29T10:50:34Z
dc.date.issued2019-11-01
dc.identifier.citationCellular and Molecular Life Sciences 76 (2019): 4423–4446en_US
dc.identifier.issn1420-682X (print)en_US
dc.identifier.issn1420-9071 (online)en_US
dc.identifier.urihttp://hdl.handle.net/10486/690917
dc.description.abstractAccumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an extensive number of non-GPCR cellular partners. GRK2 multifunctionality arises from its multidomain structure and from complex mechanisms of regulation of its expression levels, activity, and localization within the cell, what allows the precise spatio-temporal shaping of GRK2 targets. A better understanding of the GRK2 interactome and its modulation mechanisms is helping to identify the GRK2-interacting proteins and its substrates involved in the participation of this kinase in different cellular processes and pathophysiological contextsen_US
dc.description.sponsorshipOur laboratories are supported by Ministerio de Ciencia, Innovación y Universidades (Grant SAF2017-84125-R to FM and SAF2017-82886-R to FSM), CIBERCV-Instituto de Salud Carlos III, Spain (Grant CB16/11/00278 to F.M, co-funded with European FEDER contribution), Instituto de Salud Carlos III, Spain (Grant PI17-00576 to PP and grant PI18/01662 to CR), Fundacion Ramón Areces (to FM) and Programa de Actividades en Biomedicina de la Comunidad de Madrid-B2017/BMD-3671-INFLAMUNE to FM and FSM. We also acknowledge institutional support to the CBMSO from Fundación Ramón Arecesen_US
dc.format.extent24 pag.en_US
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherBirkhaeuser Scienceen_US
dc.relation.ispartofCellular and Molecular Life Sciencesen_US
dc.rights© 2019, The Author(s)en_US
dc.subject.otherGPCRen_US
dc.subject.otherGRK2en_US
dc.subject.otherHDAC6en_US
dc.subject.otherInteractomeen_US
dc.subject.otherPhosphorylationen_US
dc.titleG protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling huben_US
dc.typearticleen
dc.subject.ecienciaBiología y Biomedicina / Biologíaes
dc.relation.publisherversionhttps://doi.org/10.1007/s00018-019-03274-3
dc.identifier.doi10.1007/s00018-019-03274-3
dc.identifier.publicationfirstpage4423
dc.identifier.publicationissue22
dc.identifier.publicationlastpage4446
dc.identifier.publicationvolume76
dc.relation.projectIDGobierno de España. SAF2017-84125-Res_ES
dc.relation.projectIDGobierno de España. SAF2017-82886-Res_ES
dc.relation.projectIDGobierno de España. CB16/11/00278es_ES
dc.relation.projectIDComunidad de Madrid. B2017/BMD-3671-INFLAMUNEes_ES
dc.relation.projectIDGobierno de España. PI17-00576es_ES
dc.relation.projectIDGobierno de España. PI18/01662es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimientoes_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMPenela Márquez, Petronila (260945)
dc.authorUAMRibas Núñez, Catalina (260856)
dc.authorUAMSánchez Madrid, Francisco (259404)
dc.authorUAMMayor Menendez, Federico (260516)
dc.facultadUAMFacultad de Ciencias
dc.institutoUAMCentro de Biología Molecular Severo Ochoa (CBMSO)


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