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dc.contributor.authorSetaro, Francesca
dc.contributor.authorWennink, Jos W.H.
dc.contributor.authorMäkinen, Petri I.
dc.contributor.authorHolappa, Lari
dc.contributor.authorTrohopoulos, Panagiotis N.
dc.contributor.authorYlä-Herttuala, Seppo
dc.contributor.authorVan Nostrum, Cornelus F.
dc.contributor.authorDe La Escosura, Andres
dc.contributor.authorTorres Cebada, Tomás 
dc.contributor.otherUAM. Departamento de Química Orgánicaes_ES
dc.date.accessioned2020-05-20T10:50:59Z
dc.date.available2020-05-20T10:50:59Z
dc.date.issued2020-01-14
dc.identifier.citationJournal of Materials Chemistry B 8.2 (2020): 282-289en_US
dc.identifier.issn2050-7518 (online)en_US
dc.identifier.issn2050-750X (print)en_US
dc.identifier.urihttp://hdl.handle.net/10486/691072
dc.description.abstractIn this paper we describe a straightforward supramolecular strategy to encapsulate silicon phthalocyanine (SiPc) photosensitizers (PS) in polymeric micelles made of poly(ϵ-caprolactone)-b-methoxypoly(ethylene glycol) (PCL-PEG) block copolymers. While PCL-PEG micelles are promising nanocarriers based on their biocompatibility and biodegradability, the design of our new PS favors their encapsulation. In particular, they combine two axial benzoyl substituents, each of them carrying either three hydrophilic methoxy(triethylenoxy) chains (1), three hydrophobic dodecyloxy chains (3), or both kinds of chains (2). The SiPc derivatives 1 and 2 are therefore amphiphilic, with the SiPc unit contributing to the hydrophobic core, while lipophilicity increases along the series, making it possible to correlate the loading efficacy in PCL-PEG micelles with the hydrophobic/hydrophilic balance of the PS structure. This has led to a new kind of third-generation nano-PS that efficiently photogenerates 1O2, while preliminary in vitro experiments demonstrate an excellent cellular uptake and a promising PDT activity.en_US
dc.description.sponsorshipThis work was supported by EU (CosmoPHOS-nano, EU-FP7-NMP-2012-LARGE-6, 310337), the Spanish MINECO (CTQ2017-85393-P (TT), CTQ-2014-53673-P and CTQ-2017-89539-P (AdlE), PCIN-2017-042/EuroNanoMed2017-191, TEMPEAT (TT)), and Finnish Cultural Foundation. IMDEA Nanociencia acknowledges support from the ‘Severo Ochoa’ Programme for Centres of Excellence in R&D (MINECO, Grant SEV-2016-0686)en_US
dc.format.extent8 pag.en_US
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofJournal of Materials Chemistry Ben_US
dc.rights© 2019 The Royal Society of Chemistry.en_US
dc.subject.otherBiocompatibilityen_US
dc.subject.otherBiodegradabilityen_US
dc.subject.otherBlock copolymersen_US
dc.subject.otherEthyleneen_US
dc.subject.otherEthylene glycolen_US
dc.subject.otherHydrophobicityen_US
dc.subject.otherPhotosensitizersen_US
dc.subject.otherPolyethylene glycolsen_US
dc.subject.otherPolyethylene oxidesen_US
dc.subject.otherSilicon compoundsen_US
dc.subject.otherSupramolecular chemistryen_US
dc.subject.otherMicellesen_US
dc.titleAmphiphilic phthalocyanines in polymeric micelles: A supramolecular approach toward efficient third-generation photosensitizersen_US
dc.typearticleen
dc.subject.ecienciaQuímicaes_ES
dc.date.embargoend2020-11-11
dc.relation.publisherversionhttps://doi.org/10.1039/C9TB02014Des_ES
dc.identifier.doi10.1039/C9TB02014Des_ES
dc.identifier.publicationfirstpage282
dc.identifier.publicationissue2
dc.identifier.publicationlastpage289
dc.identifier.publicationvolume8
dc.relation.projectIDGobierno de España. CTQ2017-85393-Pes_ES
dc.relation.projectIDGobierno de España. CTQ-2014-53673-Pes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/310337en_US
dc.relation.projectIDGobierno de España. CTQ-2017-89539-Pes_ES
dc.relation.projectIDGobierno de España. SEV-2016-0686es_ES
dc.relation.projectIDGobierno de España. PCIN-2017-042/EuroNanoMed2017-191es_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.rights.accessRightsopenAccessen
dc.authorUAMEscosura Navazo, Andrés De La (263314)
dc.authorUAMTorres Capelli, María Del Mar (264472)
dc.facultadUAMFacultad de Ciencias
dc.institutoUAMInstituto de Investigación Avanzada en Ciencias Químicas (IAdChem)


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