Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals
Entity
UAM. Departamento de Química OrgánicaPublisher
Wiley - VCH Verlag GmbH & Co. KGaADate
2017-03-28Citation
10.1002/chem.201605285
Chemistry - A European Journal 23.18 (2017): 4320-4326
ISSN
1521-3765DOI
10.1002/chem.201605285Funded by
A.d.l.E. acknowledges a Ramón y Cajal contract from the Spanish Ministry of Economy (MINECO). The work at Madrid was supported by the EU [SO2S (FP7‐PEOPLE‐2012‐ITN, 316975); and CosmoPHOS‐nano (FP7‐NMP‐2012‐6, 310337‐2)], the Spanish MINECO [CTQ‐2014‐52869‐P (T.T.) and CTQ‐2014‐53673‐P (A.d.l.E.)] and Comunidad de Madrid [FOTOCARBON (S2013/MIT‐2841)]. J.M., V.L., and M.A.K. acknowledge support through the Emil Aaltonen Foundation and the Academy of Finland (grants 267497, 273645 and 263504). This work was supported by the Academy of Finland through its Centers of Excellence Programme (2014–2019) and made use of the Aalto University Nanomicroscopy Centre (Aalto NMC). The work in Barcelona was supported by the Spanish MINECO (grant CTQ2013‐48767‐C3‐1‐R). R.B.‐O. thanks the European Social Funds and the SUR del DEC de la Generalitat de Catalunya for his predoctoral fellowship (2016 FI B1 00021).Project
info:eu-repo/grantAgreement/EC/FP7/316975; info:eu-repo/grantAgreement/EC/FP7/310337‐2; Gobierno de España. CTQ‐2014‐52869‐P; Gobierno de España. CTQ‐2014‐53673‐P; Comunidad de Madrid. S2013/MIT‐2841Editor's Version
https://doi.org/10.1002/chem.201605285Subjects
Supramolecular complex; Phthalocyanines; Photoantimicrobial biohybrids; Functional materials; Cellulose nanocrystals; QuímicaNote
This is the peer-reviewed version of the following article: Anaya‐Plaza, E., van de Winckel, E., Mikkilä, J., Malho, J. M., Ikkala, O., Gulías, O., ... & Kostiainen, M. A. (2017). Photoantimicrobial biohybrids by supramolecular immobilization of cationic phthalocyanines onto cellulose nanocrystals. Chemistry–A European Journal, 23(18), 4320-4326., which has been published in final form at https://doi.org/10.1002/chem.201605285. This article may be used for non-commercial purposes in accordance with Wiley-VCH Terms and Conditions for Self-ArchivingRights
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimAbstract
The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non-covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non-covalent biohybrids show strong photodynamic activity against S. aureus and E. coli, representative examples of Gram-positive and Gram-negative bacteria, respectively, and C. albicans, a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surface
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Google Scholar:Anaya-Plaza, Eduardo
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van de Winckel, Eveline
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Mikkilä, Joona
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Malho, Jani Markus
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Ikkala, Olli
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Gulías, Oscar
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Bresolí-Obach, Roger
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Agut, Montserrat
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Nonell, Santi
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Torres Cebada, Tomás
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Kostiainen, Mauri A.
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de la Escosura, Andrés
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