Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
EntityUAM. Departamento de Cirugía
PublisherPublic Library of Science
10.1371/journal.pone.0216472PLoS ONE 14.5 (2019): e0216472
Funded byThis work was funded by grants PI10/ 0683, PI13/0127 and PI16/01650 to J.P, PI16/ 01920 to R.G.S, and PI14/00459 to MU, from the Spanish Ministry of Health and Consumer Affairs, and cofunded by the European Regional Development Fund (FEDER); it was further supported by grants CA72851, CA181572 CA184792, CA187956 and CA202797 from the National Cancer Institute, National Institute of Health; RP140784 from the Cancer Prevention Research Institute of Texas; grants from the Sammons Cancer Center and Baylor Foundation, as well as funds from the Baylor Scott & White Research Institute, Dallas, TX, USA to AG.
ProjectGobierno de España. CA72851; Gobierno de España. CA181572; Gobierno de España. CA184792; Gobierno de España. CA187956; Gobierno de España. CA202797
SubjectsColorectal cancer; Intermediate-onset; Clinicopathological; Polyps; Medicina
Rights© 2019 Arriba et al.
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Comparative studies of colorectal cancer (CRC) according to the age of onset have found differences between early-onset CRC (EOCRC) and late-onset CRC (LOCRC). Using this as a starting point, we wished to determine whether intermediate-onset CRC (IOCRC) might also be considered as an independent group within CRC. We performed a retrospective comparative study of the clinicopathological and familial features, as well as of the symptoms and their duration, of a total of 272 subjects diagnosed with CRC classified into three groups according to the age-of-onset (98 EOCRC, 83 IOCRC and 91 LOCRC). The results show that from a clinicopathological point of view, IOCRC shared certain features with EOCRC (gender, prognosis), and with LOCRC (multiple primary CRCs), whereas it also had characteristics that were specific for IOCRC (mean number of associated polyps). A gradual progression was observed from EOCRC to LOCRC from a greater family aggregation to sporadic cases, in parallel with a change of Lynch Syndrome cases to the sporadic microsatellite instability pathway, with the IOCRC being a boundary group that is more related to EOCRC. With respect to symptoms, duration and correlation with stages, IOCRC appeared more similar to EOCRC. Clinically, IOCRC behaves as a transitional group between EOCRC and LOCRC, with features in common with both groups, but also with IOCRC-specific features. Excluding cases with familial cancer history, the awareness for EOCRC diagnosis should be extended to IOCRC.
Google Scholar:Arriba, María - Sánchez, Carmen - Vivas, Alfredo - Nutu, OA - Rueda, Daniel - Tapial, Sandra - Rodríguez, Yolanda - Brandáriz, Lorena - García, Juan L. - García-Olmo, Damián - Goel, Ajay - González-Sarmiento, Rogelio - Urioste, Miguel - Perea, José
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