Control of Inflammation by Calorie Restriction Mimetics: On the Crossroad of Autophagy and Mitochondria
Entity
UAM. Departamento de Biología MolecularPublisher
M D P I AGDate
2019-12-28Citation
10.3390/cells9010082
Cells 9.1 (2020): 8
ISSN
2073-4409DOI
10.3390/cells9010082Funded by
This research was funded by the H2020-EU.1.1. European Research Council (ERC-2016-StG 715322-EndoMitTalk), and Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI16/188, PI19/855), Fondo Europeo de Desarrollo Regional (FEDER). M.M. is supported by the Miguel Servet program from Instituto de Salud Carlos III (CPII19/00014, Instituto de Investigación del Hospital 12 de Octubre)Project
info:eu-repo/grantAgreement/EC/H2020/715322/EU//EndoMitTalk; Gobierno de España. CPII19/00014Editor's Version
https://doi.org/10.3390/cells9010082Subjects
Autophagy; Mitochondria; Calorie restriction; Aging; Metabolism; Inflammation; Biología y Biomedicina / BiologíaRights
© 2019 by the authorsAbstract
Mitochondrial metabolism and autophagy are two of the most metabolically active cellular processes, playing a crucial role in regulating organism longevity. In fact, both mitochondrial dysfunction or autophagy decline compromise cellular homeostasis and induce inflammation. Calorie restriction (CR) is the oldest strategy known to promote healthspan, and a plethora of CR mimetics have been used to emulate its beneficial effects. Herein, we discuss how CR and CR mimetics, by modulating mitochondrial metabolism or autophagic flux, prevent inflammatory processes, protect the intestinal barrier function, and dampen both inflammaging and neuroinflammation. We outline the effects of some compounds classically known as modulators of autophagy and mitochondrial function, such as NAD+ precursors, metformin, spermidine, rapamycin, and resveratrol, on the control of the inflammatory cascade and how these anti-inflammatory properties could be involved in their ability to increase resilience to age-associated diseases
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Google Scholar:Gabande Rodríguez, Enrique
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Gómez de las Heras, Manuel M.
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Mittelbrum Herrero, María
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